One study suggested that treating coronavirus patients with high doses of vitamin D supplements may put them out of intensive care.
Researchers gave 50 patients hospitalized with Kovid-19 in Spain a type of calcidiol – a type of vitamin D supplement.
They were given 100 micrograms of the supplement over the course of a week, 55mg on the first day and then two booster doses of 27mg on days three and seven. The dose was slightly higher than the 70mg weekly limit recommended by the NHS.
The scientists compared the health of the participants with 26 volunteers in a control group who were not given pills, which are usually prescribed to patients with thyroid or kidney problems.
Just one calcified given to a patient fell ill to be admitted to intensive care, while half of the participants in the control group were taken to the ICU and two died.
There were no deaths among volunteers receiving the vitamin and all 50 patients were discharged by the end of the study.
Experts now believe that Kovid-19 causes a catastrophic buildup of a chemical called bradykinin, which leaks blood vessels and increases the risk of inflammation.
Calcifediol is one of the few hormones that regulates bradykinin and may also prevent the immune system from going into overdrive.
Researchers have split on whether vitamin D deficiency, which is important for the immune system, may increase the risk of Kovid-19 dying. Some scientists suggested that this may be one reason why black people are at greater risk of dying from the disease, as they do not naturally overproduce vitamins.
Taking too much vitamin D can cause bone and limb damage over time, and scientists discourage people from trying to self-medicate.
Calcifediol – a type of vitamin D supplement – appeared to reduce the risk of a Kovid-19 patient when intensive doses are required, when given in large doses, a study in Spain found (of the drug Stock image)
For the study, researchers at the University of Cordoba in Spain and the Research University KU Leuven in Belgium monitored 76 hospital patients with Kovid-19.
Fifty of the patients were randomly assigned to general care as well as calcifediol tablets.
Twenty-six volunteers were placed in a control group who received only standard care to compare treatments.
Because the study was conducted several months ago, the standard care for coronovirus in Spain was hydroxychloroquine and azochromycin. These two drugs have since proved ineffective in treating the virus.
A high calcified calcified dose of 50 micrograms was given on the first day and then 26 micrograms on the third and seventh days. These patients were given medication at this dose until they were discharged.
The NHS advises people not to take more than 70 micrograms of vitamin D a week, as it warns that it can damage bone and limb over time.
VITAMIN D DEFICIENCY PLACE SPORT FOR ‘GAME RISE-19 PA RISK’
BAME people may be at greater risk of dying from coronavirus because they are more likely to be deficient in vitamin D, scientists claim.
The epidemic is seeing higher rates of people from black, Asian and minority ethnic backgrounds if they catch coronaviruses.
The reasons are still unknown and will likely be many more complex. But some experts believe that vitamin D deficiency may play a role.
People with dark skin need to spend more time in sunlight to get the same amount of vitamin D as a person with light skin.
For this reason, the NHS suggests that people with an African, African-Caribbean or South Asian background may benefit from taking daily supplements throughout the year.
Vitamin D may have a protective effect against severe coronaviruses by regulating the immune system, and its deficiencies have been linked to other respiratory viruses.
However, the largest study to examine the link between BAME, covid-19 and vitamin D in the UK population found no evidence.
William Henley, Professor of Medical Statistics at the University of Exeter, said the MailOnline link is worth exploring.
He said: ‘Preliminary research suggests that vitamin D levels may also affect the risk of people suffering from severe COVID-19 infection.
‘In the UK and northern European latitudes, vitamin D deficiency is a public health concern because ultraviolet B (UVB) radiation is insufficient for vitamin D synthesis in the winter months.
‘This is of particular concern to people with darker skin, such as people of African, African-Caribbean or South Asian descent, who must produce the same amount of vitamin D in sunlight as someone with lighter skin. To the person. ‘
Calcifediol is a hormone produced in the liver in response to vitamin D being absorbed by the body. Giving calcifidol directly to people stops the process where the body converts vitamins into hormones.
The scientists behind the paper, to be published in the journal Steroid Biochemistry and Molecular Biology, are now calling Cafidiol to prescribe all Kovid-19 patients with lung damage.
Professor Jose Manuel Cusada Gomez, one of the study’s authors, told ThePrint: ‘Vitamin D3 is converted by the liver into calcidiol. However, administering calcified directly instead of vitamin D3 rapidly restores hormone levels in the blood.
‘It also has a more reliable intestinal absorption. This means that the body is more likely to absorb calcifediol than vitamin D3. ‘
However, critics said the results were not definitive despite being ‘interesting’.
Dr. of the Indian Institute of Science Education and Research (IISER) in Pune. Satyajit Rath said: ‘This is a very small group of patients. It does not identify the degree of severity of Kovid-19 in patients at the time of admission, and provides no details of their clinical progress other than ICU admission and death.
They also picked up perforations in the methodology, pointing out that the study did not specify co-morbidities that the test patients were suffering from.
Researchers instead chose to loop all comorbidities together, giving them similar risk factors for Kovid.
This, we know, is not the case with viruses. For example, an obese patient is more likely to suffer an infection than a person with a psychiatric disorder.
The study also did not reveal what comorbidities, if any, were offered to patients admitted to the ICU.
“In such a small group, small differences between the two groups may be sufficient to reduce the result,” he said.
Professor SP Kalantri, director of medicine at Mahatma Gandhi Institute of Medical Sciences in Maharashtra, India, pointed out other flaws in the study’s findings.
He said researchers did not measure vitamin D levels before or after the administration of the drug.
The professor also claimed that ICU admission was not a good scientific measure of the severity of the disease, as the threshold for admission varies wildly between countries, hospitals and doctors.
“What is the progression of the disease is measured in most clinical trials, suggesting that patients need oxygen, high-flow nasal oxygen, mechanical ventilation, or died,” he said.
The researchers behind the Spanish study said they were putting together larger clinical trials to test calcifidal in more stringent studies.
Vitamin D is believed to prevent the nasty symptoms of Kovid-19, forming a chemical called bradykinin, which helps control blood pressure.
This leads to a catastrophic accumulation of the chemical, causing a ‘bradykinin storm’, which seeps blood vessels and increases the risk of inflammation, blood clots, stroke, and brain damage – observed in the most fatal patients Symptoms.
As bradykinin accumulates in the body, it makes the protective walls around the blood vessels less waterproof and more likely to leak.
This causes immune cells to leak into vital organs like the lungs, causing lethal inflammation – a useful recovery process when well controlled – that makes breathing difficult.