Vitamin D levels in the blood can predict future health risks and death


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According to a study being presented in E-ECE 2020, increasing vitamin D levels in the blood in men with aging may be a better predictor of future health risks. These data suggest a free, predictive form of vitamin D found in the bloodstream. One is to make more accurate predictions about future health and disease risk, often compared to measured total vitamin D. As vitamin D deficiency is associated with many serious health conditions, as we get older, this study suggests that further investigation of vitamin D levels and their link to poor health can be a promising area for further research.

Vitamin D deficiency is common in Europe, especially among elderly people. It is associated with a high risk for developing many age-related diseases, such as heart disease, cancer, and osteoporosis. Although there are many forms or metabolites of vitamin D in the body, it is the total amount of these metabolites that are most often used to assess the vitamin D status of people. The prohormone, 25-dihydroxyvitamin D, is converted to 1,25-dehydroxyvitamin D, which is considered the active form of vitamin D in our body. More than 99% of all vitamin D metabolites in our blood are bound to proteins, so only a very small fraction is free to be biologically active. Therefore the free, active form can be a better predictor of present and future health.

Dr. from University Hospitals Leuven, Belgium. Leon Antonio and a team of colleagues investigated whether free metabolites of vitamin D were a better health predictor, using data from the European Male Aging Study, which was collected from 1,970 community-dwelling men in the 40-age group. Were of 79, between 2003 and 2005. Total and free metabolites levels of vitamin D were compared with their current health status, adjusting for potentially confounding factors, including age, body mass index, smoking, and self-reported health Were. Overall levels of free and bound vitamin D metabolites were associated with a higher risk of death. However, only free 25-hydroxyvitamin D was a predictor of future health problems and 1,25-dihydroxyvitamin D was not free.

Dr. Antonio explains, “These data further confirm that vitamin D deficiency is associated with negative effects on general health and may lead to higher risk of death.”

As this is an observational study, the causal relationship and underlying mechanisms are undefined. It was also not possible to obtain specific information about the causes of death of men in the study, which could be a confusing factor.

“Most studies focus on the association between total 25-hydroxyvitamin D levels and age-related disease and mortality. As 1,25-dehydroxyvitamin D is the active form of vitamin D in our body, it was possible that it could have been a strong predictor for disease and mortality. If total or free vitamin D levels should be measured, it has also been debated. Our data now suggest that total and free 25-hydroxyvitamin D levels are better measures of future health risks in men, ”Dr. Says Antonio.

Dr. Antonio and his team are currently finalizing statistical analysis and writing a manuscript on these findings.

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abstract

Free 25-hydroxyvitamin D, but free 1.25-dehydroxyvitamin D, does not predict all-cause mortality in aging men.

Leon Antonio, Marianne Desiger, Roger Baulon, Frederick Wu, Terence O’Neill, Stephen Pye, Ilpo Hahtanimi, Giulia Rastrelli, Gianni Forti, Felda Casanueva, Jolanta Slovicoska-Hilczer, Jose Touron, Jorn Tourn, Dirren, Duron, Dirren. Kluwen, University of Manchester, Imperial College London, University of Florence, Universitad de Santiago de Compostela, Medical University of? ?D ?, University of Tartu

Background: A total of 25 hydroxyvitamin D (25 (OH) D) and a total of 1.25 dihydroxyvitamin D (1.25 (OH) 2D) are associated with all-mortality. The hypothesis of free hormones suggests that only the free vitamin D fraction can enhance its biological function. Some recent studies suggested that free 25 (OH) D levels may be a better predictor for clinical outcomes, including mortality.

Objective: To study the association between total-free 25 (OH) D and 1.25 (OH) 2D in a prospective association of community-dwelling European men.

Methods: Between 190-50 participates in the European Male Aging Study (EMAS), men from the age group of 40- to 4 years of age participated in the European Male Aging Study (EMAS). In 5 of the 5 EMAS centers, survival status was available until 1 April 2018. A total of 25 (OH) D levels were measured by radioimmunoassay and recalculated to the NIST standard reference material. A total of 1.25 (OH) 2D was measured by mass spectrometry and immunodiffusion by vitamin D binding protein (DBP). Free 25 (OH) D and free 1.25 (OH) 2D were calculated from total hormone and DBP concentration. Measurements of vitamin D and DBP were divided into quintiles. The Cox proportional hazards model was used to study the association between vitamin D status and all-cause mortality. Due to the wide age range in inclusion, age was used as a time scale rather than years since inclusion. Results were expressed as hazard ratios (HRs) with 95% confidence intervals adjusted for center, BMI, smoking, and self-report health.

Result: 524 (26.6%) men died during 12.3 24.7.9 years. Men who died had a BMI (p = 0.002) and a low physical activity level (p <0001), but there was no difference in smoking status. Men with the lowest total 25 (OH) D and the lowest total 1.25 (OH) 2D quintals (cutoff <9.3 μg / L and <46 ng / L, respectively) had an increased mortality (HR of males in the highest quintal). Compared) 1.83 (95% CI 1.34–2.50); P <0.001 and 1.41 (1.04–1.90); P <0.05 respectively). Similarly, the lowest three free were males in 25 (OH) D quintals (level <4. ng / L). A higher mortality risk than men at the highest quintal (HR 1.91 (1.34–2.73); P <0.001 lowest quintal). However, mortality risk was similar for all free 1.25 (OH) 2D and DBP quintals.

Conclusions: Low total 25 (OH) D levels and low total 1.25 (OH) 2D levels community housing increased future mortality in middle-aged and elderly men. However, only low free 25 (OH) D but not free 1.25 (OH) 2D levels predict all-cause mortality. Vitamin D deficiency is associated with negative effects on general health and is a predictor of high mortality risk.