Virus Vaccine Trial, Latest News: Oxford-AstraZeneca Trial to Resume in UK

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Oxford University and AstraZeneca plc has resumed the UK trial of an experimental Kovid-19 vaccine after a participant was held up over concerns that he was ill.

Oxford said in a statement that the UK Medicines Health Regulatory Authority recommended that the study be resumed after an independent review of safety data. It refused to reveal details about the volunteer’s illness.

Although temporary interruptions are common in vaccine trials, the closely-watched Astra-Oxford study found concern about the viability of one of the fastest moving experimental shots seeking protection from the epidemic. The race to develop a Kovid-19 vaccine has been narrowed to a process that typically lasts a decade, with data from the final phase of trials next month.
The statements of Astra and Oxford on Saturday did not say anything about the status of tests outside the UK trials of the Oxford vaccine in the US, Brazil, South Africa and India before being halted following a security review.

A representative for The US National Institutes of Health could not immediately be reached for comment. A spokesperson for AstraZeneca declined to comment.

Suspected diagnosis

AstraZeneca CEO Pascal Soriot said Thursday that the vaccine may still be available by the end of the year. Was an independent security board Reviewing whether the participant’s illness was caused by the vaccine or unrelated, he said.

Soriot said it was unclear whether the participant had a condition known as transverse myelitis, a suspected diagnosis. NIH director Francis Collins told a Senate committee on Wednesday that the trial was halted due to a “spinal problem”.

“We cannot disclose medical information about the disease for reasons of participant confidentiality,” Oxford said. “We are committed to the safety of our participants and the highest standards of conduct in our study and will continue to closely monitor safety.”

Oxford said some 18,000 people received “study vaccines” as part of the test. It began a large Phase 3 trial in the US in late August, aiming to recruit 30,000 people.