The former head coach of Auburn, who had considered running for governor of Alabama in 2018, has his eyes on the Senate seat currently held by Democrat Doug Jones.
Jones earned a bachelor's degree from Auburn's rival, the University of Alabama.
CNN has approached Tuberville and its campaign for comments.
The Republican primary for the seat is March 3, 2020. Rep. Bradley Byrne also announced that he would seek the Republican nomination for the Senate.
Tuberville, 64, won 159 games during his 20-year career as a head coach at Ole Miss, Auburn, Texas Tech and Cincinnati. His Auburn team in 2004 was undefeated, winning the SEC title, but went on to play in the national championship game.