Brown was known as a “Berlin patient” because he was living in a German city with both HIV and leukemia when he received treatment that apparently cured him.
While receiving chemotherapy for his cancer in 2007 and 2008, Brown became so ill that he was put into a coma. The doctors were not even sure that he would survive. Therefore, Brown transplanted stem cells from a donor who was immune to HIV in hopes of treating his cancer. Doctors declared BrownIn 2008, not long after her blood stem cell transplant.
In 2011, reporter Hank Plante with CBS San FranciscoOf Brown’s treatment. Brown said that the first person to recover from HIV made him very happy.
Co-discoverers of HIV virus Drs. Jay Levy explained this treatment, which cures Brown. “If you are able to take white cells from someone and manipulate them, then they are not infected with HIV, and those white cells become that person’s entire immune system, you are essentially called a functional cure. , “Dr. Levy said, Plante reported.
Brown said in 2011 He stopped taking his HIV medicine from the day he received the transplant and had not taken any medication since.
The cause of Brown’s death was a return to cancer that originally prompted unusual treatment to treat HIV, the AP reported.
The Berlin physician who led Brown’s historical treatment, Dr. Gero Hetters called his death a “very sad situation”, as he still seemed free of HIV.
According to the AP, Heter, who was the medical director of a stem cell company in Dresden, Germany, said, “Timothy symbolized that it is possible, under special circumstances”, to remove a patient with the virus.
In a statement on Brown’s death on Wednesday, International AIDS Society (IAS) President Adiba Kamerulzman said: “We owe Timothy and his doctor, Zero Heuter, for opening the door for scientists to explore this concept Thank you. A cure for HIV is possible. ”
While transplant treatment also “cures” another person known as a London patient, the precise method is not one that is widely available to around 38 million people worldwide.According to experts, HealthDay.
Experts reported that patients in Berlin and London benefited from a combination of medical and genetic opportunities. While the method of treatment was effective, both could easily be killed by it.
Last year, researchers isolated HIV from mice, The first time it was erased from the genome of living animals according to the study’s authors. The researchers used both CRISPR-Cas9, a gene editing system and a drug regimen, called long-acting slow-effective release (LASER) ART. Mice were treated with LASER ART and then CRISPR-Cas9, which eliminated HIV DNA from approximately one third of mice. Healthday reported that research, however, may not have the same results in humans.