Use of early, non-steroidal anti-inflammatory drugs (NSAIDs) in the coronavirus epidemic, such as ibuprofen, was not recommended due to concerns that it may lead to more severe cases of COIDID-19. However, a new study published this week in PLOS Medicine found that NSAIDs such as ibuprofen and diclofenac did not have adverse effects in people infected with COVID-19. Anti-inflammatory is usually used to treat fever and aches and pains.
“Overall, the risks for all study outcomes were similar between users and non-users of ibuprofen and other NSAIDs,” the researchers said in the published report.
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Researchers at the University of Southern Denmark, Aarhus University Hospital, and the Danish Medicine Agency collected data on more than 9,000 Danish residents with novel coronaviruses during 29 April to 27 February. They looked at registry data regarding usage. NSAIDs, according to the study, hospitalization, ICU admission, mechanical ventilation, 30-day mortality, and acute renal replacement therapy. According to the study, 248 out of 9,326 people were given a prescription for NSAIDs filled within 30 days of their positive COVID-19 test.
The researchers concluded that there was no association between the use of NSAID and the consequences of novel coronavirus infections.
“We investigated whether [the] NSAID use in a nationwide population of SARA-CoV-2 positive individuals was associated with 30-day mortality and adverse outcomes. The report, published in the study report, stated that NSAID use was not associated with an increase in 30-day mortality, which was robust across a range of complementary analyzes.
“Likewise, [the] The use of NSAIDs was not associated with risk of hospitalization, admission to ICU, mechanical ventilation or renal replacement therapy in adjusted analyzes, ”the team of researchers in the study also stated.
In a matched cohort, researchers found that 6.3% of those positive for COVID-19 used NSAIDs, compared to 6.1% of those who died did not use anti-inflammatory drugs.
In the group of people infected with COVID-19 who used NSAIDs, the researchers found that 24.5% were hospitalized and 4.9% admitted to the ICU. Meanwhile, among positive people with SARS-CoV-2 who did not take NSAIDs, 21.2% were hospitalized and 4.7% were admitted to the ICU.
“Considering the available evidence, there is no reason to withdraw the well-indicated use of NSAIDs during the SARS-CoV-2 epidemic,” the study authors stated.
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“However, particularly established adverse effects of NSAIDs, particularly their renal, gastrointestinal, and cardiovascular effects, should always be considered, and NSAIDs are used in the lowest possible dose for all patients in the shortest possible duration Must go, ”the researchers also said. Mentioned.
Currently, the US Food and Drug Administration (FDA) states on its website: “At this time, the FDA is not aware of the scientific evidence related to the use of NSVID, which worsens COVID-19 symptoms, along with the use of NSAIDs such as ibuprofen adds up. The agency is further investigating the issue and will communicate publicly when more information becomes available. However, all prescription NSAID labels warn that ‘the pharmacological activity of NSAIDs in reducing inflammation, and possibly fever, may reduce the utility of clinical signs in detecting infection.’
The FDA also recommends discussing the use of NSAIDs with your physician.