A suicide attack has killed at least 40 people and injured another 1
The attackers drove an ambulance loaded with explosives passing a police checkpoint to a street closed to the public transportation.
It happened near the old building of the Ministry of the Interior and the offices of the European Union and the Superior Council of Peace.
The Taliban have said they carried out the attack.
A week ago, Taliban militants killed 22 people in a luxury hotel in Kabul.
Witnesses say the area, where the foreign embassies and police headquarters are located, was packed with people when the bomb exploded on Saturday at about 12:15 local time (0845 GMT). Smoke columns were seen around the city.
Officials said the death toll probably would continue to rise as victims arrived at hospitals for medical attention.
The Taliban, a hard-line Islamic movement, control large areas of Afghanistan and parts of neighboring Pakistan.
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