Scientists have discovered that some psychiatric disorders such as schizophrenia, bipolar disorder can be genetic, while neurological disorders such as Parkinson's or Alzheimer's seem more defined.
"This work is beginning to change the way we think about brain disorders, if we can discover the genetic influences and patterns of overlap between different disorders, then we can better understand the root causes of these conditions and possibly identify the appropriate specific mechanisms for the adapted treatments, "said the study's lead author, Ben Neale. from the Stanley Center at the Broad Institute of MIT and Harvard in Mbadachusetts.
In the study published in the journal Science, the team measured the amount of genetic overlap among the disorders through whole genome badociation studies (GWAS) of 265,218 patients and 784,643 controls.
They also examined the relationships between brain disorders and 17 physical or cognitive measures, such as the years of education, of 1,191,588 people. Read: World Day of Schizophrenia 2018: Can Yoga Help Schizophrenics?
The results showed a generalized genetic overlap between the different types of psychiatric disorders, particularly between attention deficit / hyperactivity disorder (ADHD), bipolar disorder, depressive disorder and schizophrenia.
The data also indicated a strong overlap between anorexia nervosa and obsessive-compulsive disorder (OCD), as well as between OCD and Tourette syndrome.
In contrast, neurological disorders, except migraine, genetically correlated with ADHD, major depressive disorder and Tourette syndrome appeared to be distinct.
In addition, they observed that the genetic factors that predispose individuals to certain psychiatric disorders, namely, anorexia, autism, bipolar disorder and OCD, correlated significantly with factors badociated with higher cognitive measures of childhood, which include more years of education and university achievements. Read: World Day of Schizophrenia 2018: Growing up with schizophrenic parents
"We were surprised that the genetic factors of some neurological diseases, normally badociated with the elderly, were negatively linked to genetic factors that affect the measures It was also surprising that the genetic factors badociated with many psychiatric disorders correlated positively with educational achievement, "said the first author, Verneri Anttila of the University.
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Published: June 24, 2018 4:03 pm | Updated: June 24, 2018 4:27 pm