Researchers being used in four COVID-19 vaccine claimants – called adenoviruses 5 (Ad5) – have been shown to increase the transmission of the AIDS virus in the past, the researchers published in The Lancet Medical Journal on Monday Written in “Cautionary Tale”. .
Adenoviruses – a group of common viruses that can cause many diseases, including the common cold – are sometimes genetically engineered and used to make inoculations.
But the Ad5 strain used in a potential HIV vaccination a decade ago was found to make some people more susceptible to HIV in placebo-controlled trials, according to Science magazine.
It is unclear why Ad5 increased the risk of HIV infection in the trial, but following these findings, Drs. The National Institutes of Health, led by Anthony Fauci, recommended against the use of stress in vaccines.
Researchers are warning that more needs to be learned about this side effect before vaccination for COVID-19 to exclude vulnerable populations.
“If I were in a sub-Saharan African country and making a decision as to what I would use a SARS-CoV-2 vaccine for my country for a general population, I would not see that I would use an Ad5 vector Why would i choose [vaccine] When there are many other alternative options, ”Professor Lawrence Corey, one of the co-authors of Lancet Alert, told Science Mag.
Researchers identified four potential COVID-19 vaccines including Ad5 that are under development internationally, including the US.
California-based ImmunityBio received approval from the Food and Drug Administration last week to begin a preliminary investigation of its COVID-19 vaccine candidate, according to the LA Times. The vaccine uses Ad5 to deliver coronovirus proteins into the body to trigger an immune response that hopefully prevents infection.
However, the company’s CEO Patrick Soon-Shiong insisted that ImmunityBio’s Ad5 has four deleted genes that reduce the immune responses that trigger it.
“It’s 90% silent,” he told Science Mag.
Two other coronavirus vaccine contenders with the modified virus are currently in advanced trials in Russia and Pakistan, according to the outlet.
COVID-19 vaccines by Johnson & Johnson and AstraZeneca are currently under development, using various adenoviruses as vectors to deliver proteins.