Small insects using quantum thermometer nanodiamonds c. Feels ‘fever’ in elegans

C. The temperature of the elegans is measured through tracking of embedded nanodiamonds. Sincerely: Masazumi Fujiwara, Osaka City University

A team from the University of Osaka City, together with other international collaborators, has demonstrated a reliable, accurate, microscope-based thermometer using quantum technology that measures temperature for microscopic animals. The technology detects the temperature dependent properties of quantum spin in fluorescent nanodiamonds.

Research has been published in Science advance.

The optical microscope is one of the most basic tools for analysis in biology, which uses visible light to directly observe microstructures. In the modern laboratory, fluorescence microscopy, an enhanced version of optical microscopy using fluorescent biomarkers, is now more widespread. Recent advances in fluorescence microscopy have allowed for live imaging of the details of a structure, and through it, obtaining various physiological parameters in these structures, such as pH, reactive oxygen species, and temperature.

Quantum sensing is a technique that exploits the ultimate sensitivity of fragile quantum systems to the surrounding environment. High-contrast MRIs are examples of quantum spin in fluorescent diamonds and some of the most advanced quantum systems in real-world applications. Applications of this technique to thermal biology were introduced seven years ago to determine the temperature inside cultured cells. However, they were not yet applied to dynamic biological systems where heat and temperature are more actively involved in biological processes.

The research team decorated the surface of nanodiamonds with polymer structures and c. Elegans injected for the nematode worm, one of the most popular model animals in biology. Researchers tried to learn the healthy temperature based on insects. Once inside, nanodiamonds moved quickly, but the team’s novel quantum thermometry algorithm successfully tracked them and measured temperatures continuously. Researchers induced a fever within the worm by stimulating their mitochondria with a pharmacological treatment. The team’s quantum thermometer successfully observed temperature increases in insects.

“It was fascinating to see quantum techniques working so well in live animals, and I never imagined the temperature of small insects less than 1 mm in size that could deviate from the norm and develop into fever Maybe, ”said Masajumi Fujiwara, a lecturer at the Science Department at Osaka City University. “Our results are an important milestone that will direct the future direction of quantum sensing as it shows that it contributes to the biome,”

First quantum measurement increases by quantum entanglement

more information:
“Real-time Nanodiamond Thermometer Detection of In Vivo Thermogenic Reactions” Science advance (2020). DOI: 10.1126 / Sciadv.aba9636

Provided by Osaka City University

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