Scientists say it’s time to stop promoting the drug

With more than 150,000 deaths in COVID-19 and 4 million confirmed cases in the United States, President Donald Trump continues an unsafe treatment for coronovirus. While some treatments have been shown to improve survival or reduce disease severity, leading infectious disease specialists, doctors and virologists say it’s time to stop promoting one: hydroxychloroquine.

Told the NVR News, Emory University School of Medicine’s infectious disease physician Dr. “There is no reason for COVID-19 to keep talking about hydroxychloroquine,” Carlos Del Rio said. “It does not work for treatment or prevention. I don’t know why it is still being talked about, but it is wrong.

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Several clinical trials have failed to show that hydroxychloroquine, an anti-malarial drug approved for the treatment of lupus and rheumatoid arthritis, helps hospitalized patients. Other studies found that the drug was not useful for patients with mild disease. After warning of potentially dangerous side effects from the abuse, the Food and Drug Administration revoked its Emergency Use Authority for the drug, saying it was unlikely to be effective against the virus.

“All those trials consistently showed that hydroxychloroquine is not effective,” scientific data, cumulative data on trials, namely clinical trials that were randomly and appropriately controlled. Anthony Fauci, the country’s leading infectious disease doctor, told. Andrea Mitchell of MSNBC on Wednesday.

Yet Trump, who says he took the drug in May, preached the drug again this week during a briefing. “Many doctors think it is highly successful, combined with hydroxychloroquine zinc and perhaps azithromycin.”

Other politicians stepped into the hydroxychloroquine Fray this week. The Ohio Board of Pharmacy lifted a ban on the distribution of the drug for the treatment or prevention of COVID-19 at the request of a republican Mike Mine Dine. And Rep. Louie Gohmert, R-Texas, who was recently diagnosed with COVID-19, told Fox News late Wednesday that he, after a conversation with his doctor, received azithromycin and zinc for his infection With hydroxychloroquine. Gohart has said that he has no symptoms.

Dean of the National School of Tropical Medicine at Baylor College of Medicine in Houston, Drs. Peter Hotez said he believes the White House often brings in hydroxychloroquine because it is not willing to do the hard work necessary to prevent the outbreak. “So, as an alternative they are attracted to magical solutions like hydroxychloroquine,” Hotez told NBC News in an email. “It is a strategy born of lethargy and fear.”

There is no cure for COVID-19 and, for the 57,000 hospitalized patients currently in the US, there are concerns about the lack of proven therapies such as Remedisvir. At the same time, there is a surplus of hydroxychloroquine for coronovirus. The White House’s director of trade and manufacturing policy, Peter Navarro, told CNN this week that the US emergency stockpile is “sitting on millions of doses” of the drug.

With little evidence supporting the use of hydroxychloroquine, the FDA Commissioner, Drs. Stephen Hahn said on Thursday that it is up to a patient’s doctor.

Asked if patients should take hydroxychloroquine for COVID-19, Hahan acknowledged the potential pitfalls. “We had data that when this drug was mixed with others, there was some risk associated with it,” Hahn said on NBC’s “Today” show. “But the question you are asking me is the decision between a doctor and a patient.”

Interest in hydroxychloroquine began in March when a French scientist published a study showing that the drug with azithromycin was an effective treatment for COVID-19. The study has since been widely debated, and the scientific society that published the study later acknowledged that the article did not meet its standards.

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In early June, a study published by The Lancet showed hydroxychloroquine as having potential for not only any benefit, but also disadvantages, but the study was withdrawn following concerns about the data.

However, a look at other research repeatedly concludes that hydroxychloroquine is not an effective treatment for coronavirus, including results from three large randomized controlled trials.

On 5 June, the UK RECOVERY trial announced that the first randomized controlled trial on hydroxychloroquine showed it to be ineffective for hospitalized patients. Since then, both a trial supported by the National Institutes of Health and the World Health Organization have been suspended, as the drug patients were not better off without it.

Dr., an emergency medicine physician from Oregon Health Sciences. Esther Chu believes that making many studies difficult to sort through meaningful data can add to public confusion.

“Initial observational studies continue to be recycled,” he told NBC News in an email, telling NBC News that “it is hard for the general public to understand that these types of studies determine drug effects as controlled trials of the drug.” Are not helpful. “

Angela Rasmussen, a virologist at Columbia University, calls the politicization of hydroxychloroquine “extremely dangerous for public health”.

“It affects attention and resources from other drugs in development that may be more effective and have the worst consequences, using ineffective treatment rather than caring for COVID-19,” he wrote in the email Are. “

Researchers agree that America needs to focus on finding a treatment that works.

“The hydroxychloroquine puts the last nail in the coffin and moves on,” Del Rio said.

correction (July 30, 2020, 8:03 pm ET): A previous version of this article recalled the last name of a virologist at Columbia University. She is Angela Rasmussen, not Rasmussen.

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