A team of UK researchers have expected something in an unexpected place: a medieval manuscript.
A 1,000-year-old natural remedy made from onions, garlic, alcohol and bile salts has shown antibacterial potential, with new research published on Tuesday promising to treat diabetic foot and foot infections.
Known as Bald’s pupil, the treatment has the potential to combat biofilm infections – communities of bacteria that oppose antibiotics – making them much harder to treat, researchers said.
The study says biofilm infections are estimated to cost more than 1 billion pounds ($ 1.3 billion) each year.
Freya Harrison, a microbiologist and an author at the School of Life Sciences at the University of Warwick in the UK, said, “This real detailed hard slogan to get more information and see if it can actually be clinically useful.” is.” Of study.
“We think it’s particularly promising for the treatment of diabetic foot infections. They are the ultimate, super-resistant bio-fuel infection. They are a huge health and economic burden. They can actually go untreated. Are, “she said.
“There is a high risk that these diabetic foot ulcers are completely resistant to any antibiotic treatment. There is a risk of a person developing sepsis again … and people are dissecting their leg or lower leg . “
Initial medical lesson
“Balds Litchbook”, an old English leatherbound book held in the British Library, had a concoction between medicines, snacks and remedies for healing. It is one of the earliest known medical texts.
“When you read it as a microbiologist, you think it’s got something to do because every component in it has some antibacterial activity when you test it in a test tube. It used to be that one It is sensible to put together. ”
“It is very clearly intended for a bacterial infection from the description of symptoms in the book.”
They made the mixture using garlic and onions purchased from the general supermarket or greengrocers, while the wine was an English white. Bile salts come from the stomach of a cow.
The research project came about coincidentally with Harrison, who is fond of medieval history and enjoys historical history by listening to this book. He worked as an old English specialist at the University of Nottingham, along with former colleague Christina Lee, where Harrison worked.
“To be honest, we didn’t go into thinking that five years down the line it would be something for which we would have the money to translate. We thought it would be an interesting piece of microbiology.”
Curiously, Harrison stated that the “Balds Litchbook” also included a remedy for malaria using the worm herb, which was endemic in parts of England in the early medieval period.
“At that time all essentially the same remedy sat in an English medieval text, but no one had taken it seriously,” she said.
Antibiotics underlie modern medicine, and medical procedures such as surgery and chemotherapy can be very dangerous if they lose their effectiveness.
One of the major findings of the study was that it was a mixture of natural products, rather than a compound, which gave Bald’s eye light “powerful anti-biofilm activity”.
Harrison said the team is testing the safety of the mix and is expected to publish in preliminary research that “this is a promising safety profile,” Harrison said. The next step would then be to chemically image the mixture and initiate patch testing on human skin, but the latter was delayed by the coronovirus epidemic.
The nature, research and combination of ingredients rather than a single plant or compound can make the development and regulatory approval process more time-consuming, Harrison said.
“Next year we hope to have some ideas of chemistry, a better idea of safety, and then a case to say if it’s really effective, but I’m sure you know that this work will be long,” Harrison said.
“It’s important to recognize that the most exciting-looking, potentially anti-microbial ultimately fails to translate into a product. So we have to be very realistic and do a lot of detailed work to see if it will be useful.”