Scientists publish microscopic images of coronovirus infected cells taken from the respiratory tract


Washington: Scientists have extracted images of novel coronaviruses infecting respiratory tract cells developed in the laboratory, which extracts and describes the number of virus particles produced per cell inside the lungs. Researchers, including Camille Ehre of the University of North Carolina (UNC) Children’s Research Institute, captured these images to illustrate how SARS-CoV-2 infection of the airway can occur in very graphic and easily understood images.
The high-power microscopic images generated show a large number of virus particles on human respiratory surfaces, ready to spread infection to tissues, and others.

In the research, scientists inoculated novel coronovirus SARS-COV-2 into human bronchial epithelial cells of the lung, which they screened 96 hours later using high-power scanning electron microscopy.

Images published in the New England Journal of Medicine were re-colored, and infected hairy cells with strands of mucus attached to the cilia tips.

Scientists reported that cilia are hair-like structures on the surface of airway epithelial cells that transport mucus and trapped viruses from the lungs.

Using a high power magnification, they showed the structure and density of SARS-CoV-2 produced by the human airway epithelium.

These virus particles, the researchers said, are the complete, infectious form of the virus released on the respiratory surfaces by infected host cells.
He said that imaging research helps to show the incredibly high numbers produced and released per cell inside the human respiratory system.

According to scientists, the large viral burden is a source of infection spread to many organs of an infected person, and possibly mediates a high frequency of COVID-19 transmission to others.

He stated that the images make a strong case for the use of masks by infected and uninfected individuals to limit SARS-COV-2 transmission.

<

script type=”text/javascript”>
/* User Identification Code Start /
var _tiluuid = localStorage.getItem(‘_tiluuid’);
if (_tiluuid === null) {
function receiveMessage(evt) {
if (evt.origin === ‘https://tilanalytics.timesinternet.in’) {
_tiluuid = evt.data;
localStorage.setItem(‘_tiluuid’, _tiluuid);
}
}
window.addEventListener(‘message’, receiveMessage, false);
document.getElementById(“_tiluuid_frame”).src=”https://tilanalytics.timesinternet.in/frame_v3.min.html”;
}
/
User Identification Code End */
var objSec = {template: ‘articleshow_main’, msid:’78089057′, secNames: [‘news’,’science’],secIds:[‘2147477890′,’1715249553′,’39872847’]};

    var tmplName = tpName="articleshow_main",lang = '',nav_sec1,newHookId,subsec1_value,subsec1_common = '1715249553',newHookId2,subsec2_value,subsec2_common = '39872847';
    var objVc = {version_on:'2020091430257',js_etsubscription:'1',js_comments:'111',js_googleslock:'782',js_googlelogin:'24',js_common_buydirect:'749',js_bookmark:'18',js_login:'39',js_datepicker:'2',js_electionsmn:'22',js_push:'53',css_buydirect:'14',js_tradenow:'14',js_commonall:'117',lib_login:'https://jssocdn.indiatimes.com/crosswalk/jsso_crosswalk_legacy_0.5.9.min.js',live_tv:'{"auto_open": 1, "play_check_hour": 12, "default_tv": "1"}',global_cube:'0',global_cube_wap:'0',global_cube_wap_url:'https://m.economictimes.com/iframe_cube.cms',site_sync:'0',amazon_bidding:'1',fan_ads:'0',trackAdCode:'0',ajaxError:'1',oauth:'oauth',planPage:'https://prime.economictimes.indiatimes.com/plans',subscriptions:'subscriptions',krypton:'kryptonp',apw:'apw'};
    var objDim = {d52:'nature_of_content',d10:'user_login_status_hit',d54:'content_shelf_life',d53:'content_target_audience',d12:'tags_meta_keyword',d56:'degree_of_conten',d11:'content_theme_the_primary_tag',d55:'content_tone',d14:'special_coverage',d13:'article_publish_time',d16:'video',d15:'audio',d59:'show_paywall_final',d61:'paywall_probability',d60:'paywall_score',d63:'paid_articles_read',d62:'eligibility_paywall_rule',d65:'bureau_articles_read',d20:'platform',d64:'free_articles_read',d23:'author_id',d67:'loyalty',d66:'article_length',d25:'page_template',d24:'syft_initiate_page',d68:'paywall_hits',d27:'site_sub_section',d26:'site_section',d29:'section_id',d28:'prime_deal_code',d32:'prime_article_read_before_syft',d34:'content_age',d33:'prime_article_read_before_success',d36:'sign_in_initiation_position',d35:'subscription_method_hit',d37:'user_subscription_status',d1:'et_product',d2:'blocker_type',d3:'user_login_status',d4:'agency',d5:'author',d6:'cms_content_publishing_type',d7:'content_personalisation_level',d8:'article_publish_date',d9:'sub_section_name',d40:'freeread',d45:'prime_hp_ui_template',d47:'prime_hp_ui_content_b_color',d46:'prime_hp_ui_content_size',d49:'syft_initiate_position',d48:'content_msid',d50:'signin_initiate_page'};var serverTime="09.14.2020 03:06:36";var WRInitTime=(new Date()).getTime();
        (function () {if (self !== top) {var e = function (s) {return document.getElementsByTagName(s)}; e("head")[0].innerHTML = '<style>*{display:none;}</style>'; setTimeout(function () {e("body")[0].innerHTML = ''; var hEle = e("html")[0]; hEle.innerHTML = 'economictimes.indiatimes.com'; hEle.className=""; top.location = self.location; }, 0);}})();

    _log = window.console && console.log ? console.log : function () {};
    if(window.localStorage && localStorage.getItem('temp_geolocation')) {
        var geolocation = localStorage.getItem('temp_geolocation');
    }
    // Creating Elements for IE : HTML 5 and cross domain checks
    (function () { var elem = ["article", "aside", "figure", "footer", "figcaption", "header", "nav", "section", "time"];
        for(var i=0; i<=elem.length-1; i++) {document.createElement(elem[i])} var hd = 'indiatimes.com', dd = document.domain,intv,intv2,fo; if (dd != hd && dd.indexOf(hd) != -1) {document.domain = hd} })();
    var intv,intv2;var fo;
    if(subsec1_value == '1715249553' && subsec2_value == '1052732854'){
        subsec1_value = newHookId = '1052732854'; // politicsnation
    }else if(subsec1_value == '1715249553' && subsec2_value == '1373380680'){
        subsec1_value = newHookId = '1373380680'; // Economy
    }


                var _gaq = _gaq || [];
                var customDimension = customDimension || {};
                var analytics_js_path="https://www.google-analytics.com/analytics.js";
                (function(i,s,o,g,r,a,m){i['GoogleAnalyticsObject']=r;i[r]=i[r]||function(){
                  (i[r].q=i[r].q||[]).push(arguments)},i[r].l=1*new Date();a=s.createElement(o),
                  m=s.getElementsByTagName(o)[0];a.async=1;a.src=g;m.parentNode.insertBefore(a,m)
                  })(window,document,'script',analytics_js_path,'ga');
                  var gaProperty = 'UA-198011-5';
                  var disableStr="ga-disable";
                  if (document.cookie.indexOf(disableStr + '=true') > -1) { window[disableStr + '-' + gaProperty] = true; }

                  ga('set', 'anonymizeIp', true);
                  ga('create', gaProperty, 'auto', {'allowLinker': true});
                  ga('require', 'linker');
                  ga('linker:autoLink', ['economictimes.com']);
                  ga('require', 'displayfeatures');
                  window.optimizely = window.optimizely || [];
                  window.optimizely.push("activateUniversalAnalytics");
                  ga('require', 'GTM-KS2SX8K');

                  customDimension.dimension1 = "ET Free";
    customDimension.dimension4 = "PTI";

    customDimension.dimension6 = "Native - 78089057";
    customDimension.dimension8 = "Sep 13, 2020";
    customDimension.dimension9 = "Science";

    customDimension.dimension12 = "respiratory tract cells,University of Washington,novel coronavirus,coronavirus,The New England Journal of Medicine,the university of north carolina";
    customDimension.dimension13 = "03:49 PM IST";

    customDimension.dimension15 = "No"; 
    customDimension.dimension16 = "No"; 

                    (function () {
                        var a = window.localStorage && localStorage.getItem('et_syftCounter') || '';
                        a = a && JSON.parse(a) || {};
                        if(a.beforeSyft) {
                            customDimension.dimension32 = a.beforeSyft;
                        }
                        if(a.afterSyft) {
                            customDimension.dimension33 = a.afterSyft;
                        }
                    })()

                        var contentAge="0.3767476851851852";
                        if(contentAge) {
                            customDimension.dimension34 = contentAge > 2 ? '>48hs':'<48hrs';
                        }

                    customDimension.dimension25 = "articleshow_main";
                    customDimension.dimension26 = "News";
                    customDimension.dimension27 = "News/Science/";
                    customDimension.dimension29 = "1715249553";
                    customDimension.dimension48 = "78089057";
                    customDimension.dimension57 = _tiluuid;
                    ga('send', 'pageview', customDimension);
                    ga('create', 'UA-5594188-55', 'auto','ETPTracker'); //ETPrime GA

                        var newHookId ='1715249553';
                        var newHookId2 = '39872847';

                            if(newHookId == '1715249553' && newHookId2 == '1052732854'){
                                newHookId = '1052732854'; // politicsnation
                            }else if(newHookId == '1715249553' && newHookId2 == '1373380680'){
                                newHookId = '1373380680'; // Economy
                            }


                        var subsec1_value="1715249553";
                        var subsec1_2value="39872847";

                            if(subsec1_value == '1715249553' && subsec1_2value == '1052732854'){
                                subsec1_value="1052732854"; // politicsnation
                            }else if(subsec1_value == '1715249553' && subsec1_2value == '1373380680'){
                                subsec1_value="1373380680"; // Economy
                            }



    (function (g, r, o, w, t, h, rx) {
        g
        }, g
        g
        h.async = 1;h.src = w;rx.parentNode.insertBefore(h, rx)
    })(window, document, 'script', 'https://static.growthrx.in/js/v2/web-sdk.js', 'grx');
    grx('init', 'gf999c70d');
    var grxDimension = {url: window.location.href, title : document.title, referral_url : document.referrer};

    if(window.customDimension && window.objDim) {
        for(key in customDimension) {
            var dimId = 'd' + key.substr(9, key.length);
            if(objDim[dimId] && customDimension[key]) { grxDimension[objDim[dimId]] = customDimension[key]; }
        }
    }

        var subsStatus="Free User";
        var jData = JSON.parse(localStorage.getItem('jStorage'));
        function getCookie(n) {var ne = n + "=", ca = document.cookie.split(';');for (var i=0;i< ca.length;i++){ var c = ca[i]; while (c.charAt(0) == ' ') c = c.substring(1, c.length); if (c.indexOf(ne) == 0) return c.substring(ne.length, c.length); } return null; }
        (function () {
            if(ssoid = getCookie('ssoid')) {
                try {
                    grx('userId', ssoid);
                    var pfuuid = getCookie('pfuuid');
                    if(pfuuid) { grxDimension['et_uuid'] = pfuuid}

                    grxDimension['user_login_status'] = 'LOGGEDIN';
                    var grx_userData = jData['prime_'+getCookie('TicketId')];
                    grx_userData = grx_userData || {};
                    var grx_userPermission = grx_userData.permissions;
                    if(grx_userPermission.indexOf("expired_subscription") > -1) {
                        subsStatus="Expired User";
                    } else if (grx_userPermission.indexOf("subscribed") > -1 && grx_userPermission.indexOf("cancelled_subscription") > -1 && grx_userPermission.indexOf("can_buy_subscription") > -1) {
                        subsStatus="Paid User - In Trial";
                    } else if(grx_userPermission.indexOf("subscribed") > -1) {
                        subsStatus="Paid User";
                    } else if(grx_userPermission.indexOf("etadfree_subscribed") > -1) {
                        subsStatus="Ad Free User";
                    }
                } catch (e) {}
            } else {
                grxDimension['user_login_status'] = 'NONLOGGEDIN';
            }
            grxDimension['user_subscription_status'] = subsStatus;
        })()

    grx('track', 'page_view', grxDimension);


if(geolocation && geolocation != 5 && (typeof skip == 'undefined' || typeof skip.fbevents == 'undefined')) {
    !function(f,b,e,v,n,t,s)
    {if(f.fbq)return;n=f.fbq=function(){n.callMethod?
    n.callMethod.apply(n,arguments):n.queue.push(arguments)};
    if(!f._fbq)f._fbq=n;n.push=n;n.loaded=!0;n.version='2.0';
    n.queue=[];t=b.createElement(e);t.async=!0;
    t.src=v;s=b.getElementsByTagName(e)[0];
    s.parentNode.insertBefore(t,s)}(window, document,'script',
    'https://connect.facebook.net/en_US/fbevents.js');
    fbq('init', '338698809636220');
    fbq('track', 'PageView');
}


        var _comscore = _comscore || [];
        _comscore.push({ c1: "2", c2: "6036484"});

        if(geolocation && geolocation != 5) {
            (function() {
                var s = document.createElement('script'), el = document.getElementsByTagName("script")[0]; s.async = true;
                s.src = (document.location.protocol == "https:" ? "https://sb" : "http://b") + ".scorecardresearch.com/beacon.js";
                el.parentNode.insertBefore(s, el);
            })();
        }



            if(geolocation && geolocation != 5) {

                (function(){
                    function pingIbeat() {
                        window._pg_endpt=(new Date()).getTime();
                        var e = document.createElement('script');
                        e.setAttribute('language', 'javascript');
                        e.setAttribute('type', 'text/javascript');
                        e.setAttribute('src', "https://agi-static.indiatimes.com/cms-common/ibeat.min.js");
                        document.head.appendChild(e);
                    }
                    if(typeof window.addEventListener == 'function') {
                        window.addEventListener("load", pingIbeat, false); 
                    } else {
                        var oldonload = window.onload;
                        window.onload = (typeof window.onload != 'function') ?
                        pingIbeat : function() { oldonload(); pingIbeat(); };
                    }

                })();
            }

    </script>        .