Scientists find out what happens in the skin when eczema occurs

Scientists have pointed out a bunch of procedures that go wrong in the skin for people who have eczema (also known as atopic dermatitis), and it can help us detect that How to combat the chronic situation.

Back in 2006, researchers found a strong correlation between people with a certain skin protein deficiency and the risk of developing eczema. And in 2017, scientists made the results based on what actually goes wrong, and their results may take us closer to treating an eczema.

Eczema is a common skin condition affecting 20 percent of children and 3 percent of adults worldwide. Although there is no shortage of creams and lotions that help alleviate the chronic symptoms of eczema, we have not found any treatment that can clean it properly.

For the past decade, scientists have known that eczema is associated with a genetic deficiency of phalogragin (filament aggregating protein) in the skin. This protein helps shape individual skin cells, and plays an important role in our skin’s barrier function.

If a person has a genetic mutation that inhibits the supply of the appropriate flagregin, they may develop a skin condition such as eczema or ichthyosis vulgaris, where the skin cells do not shed, and instead have patterns that look like fish scales. They pile up.

But until recently, researchers were not sure how eczema actually develops when there is a deficiency of phylagrain.

The breakthrough came in 2016, when scientists at the University of Newcastle in the UK, in collaboration with GSK Stifel, tracked a series of protein and molecular pathways that lead to this insufficient skin problem.

“We have shown for the first time that loss of filigrin protein alone is sufficient to activate the main protein and pathway,” reported Newcastle University lead researcher Nick Reynolds.

To track these mechanisms, the team used a lab-created three-dimensional living skin equivalent (LSE) model. They changed the upper layer of this lab-made to skin to be filargarin-deficient, just as it is in people who perform genetic mutations.

They found that this deficiency can trigger a host of molecular changes in important regulatory mechanisms in the skin. This affected cell structure, barrier function and even how cells respond and respond to stress.

“Specifically, for the first time, we have identified 17 proteins that are expressed after considerable differences. [filaggrin removal] In LSE Cultures, ”the team wrote in their 2017 paper.

The researchers then verified their preliminary findings by analyzing proteins in skin samples from real humans by comparing results between participants with eczema and healthy subjects.

He found that many of the proteins he came to know of had been transformed into only those with eczema – such as laboratory-based models demonstrated.

While this is the next piece of the puzzle in terms of a deeper understanding of eczema-like conditions, it is indeed a promising step.

Once scientists find out what is going on in the skin if you have the faulty flagregin gene, they can start looking for drugs that can stop it from happening.

The British Association of Dermatologists said in a statement, “This type of research allows scientists to develop treatments that target the real causes of the disease, rather than managing its symptoms.”

If you are suffering from random bouts of dermatitis, this is a really exciting possibility.

The study was published in Journal of Allergy and Clinical Immunology.

A version of this article was first published in May 2017.


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