Washington: A team of researchers recently discovered new genes related to the life expectancy of parents, which may one day be objective to help prolong human life.
According to the University of Exeter Devon, researchers from southwestern England, United Kingdom, genetics and how long our paternal relatives lived also plays a role. Now, the number of genes we know influences life expectancy has expanded, possibly paving the way to new therapeutic goals to prolong life.
The team studied 389,166 volunteers who participated in the UK Biobank, with confirmation in the US Health and Retirement Study. UU And the Wisconsin Longitudinal Study. They conducted a genome-wide search of variants that influence how long the parents of the participants lived.
The DNA samples of the volunteers carry the genetics of their biological parents, so they provide a practical way to study lives of exceptionally long duration. Eight genetic variants had already been linked during life, mainly involved in heart disease and dementia.
The latest study has expanded this to 25 genes in total, with some specific to the lives of mothers or fathers separately. The study's author, Dr. Luke Pilling, said: "We have identified new pathways that contribute to survival and we confirm others." These goals, including inflammatory and cardiovascular mechanisms, offer potentially modifiable goals to reduce the risk of premature death and improve health". 19659002] The genes involved in senescence, the "frozen" state in which cells enter after being damaged, played an important role in longevity. Genes related to inflammation and genes related to autoimmunity were also prominent, opening the possibility that precision anti-inflammatory treatments may one day be useful for prolonging life.
The results confirm that many genetic variants combine to influence human life: no variant of a single gene was found to be responsible. The study found evidence suggesting that genetic variants for average life expectancy also influence exceptionally long life expectancy.
A genetic risk score that combines the ten major variants was statistically associated with parents who are centenarians. Lead researcher David Melzer said the study helps break new ground, but that the role of genes that affect heart risk underscores the importance of controlling blood pressure and cholesterol levels throughout life.
Of course, the adoption of healthy lifestyles is important, and it can probably overcome the negative effects of most of the genes found so far, the researchers concluded.
The research appears in the magazine Aging NY.