Scientists at the University of Pittsburgh have detected antibodies that ‘neutralize’ coronaviruses


Researchers at the University of Pittsburgh School of Medicine have isolated an antibody component that “completely and specifically neutralizes the SARS-CoV-2 virus” and says its potentially viable therapeutic against coronavirus and Can be used as an anticoagulant.


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The antibody component, which is 10 times smaller than a full-size antibody, has been used to make drug A8. Researchers reported in the journal Cell on Monday that the drug is effective in preventing and treating coronovirus in rats and hamsters. Scientists say that the drug also does not attach to human cells, suggesting that it will not have negative effects in humans.

The small size of the component makes it possible that the drug can be developed as a mist or injected drug rather than a mist.

Co-author of the study and head of the Department of Infectious Diseases, John Mellors, “AB8 not only has potential as a therapy for COVID-19, but also its use to protect people from SARS-COV-2 infection.” can be done.” University of Pittsburgh Medical Center and Pitt, said in a Statement.

“Large-sized antibodies have worked against and tolerate other infectious diseases, we hope that this can be an effective treatment for patients with COVID-19 and for the protection of those who ever had The infection has not occurred and is not immune, ”she said.


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The drug was researched with researchers at the University of Chapel Hill (UNC), North Carolina, at the University of Texas Medical Branch (UTMB) at Galveston, University of British Columbia and University of Saskatchewan.

Researchers at UTMB’s Center for Biodefense and Emerging Diseases and Galveston National Laboratory tested the drug and found that it prevents the virus from entering cells, while UNC researchers found AB8 in mice even at the lowest doses The amount of infectious virus decreased by 10 times.

“The COVID-19 epidemic is a global challenge facing humanity, but biomedical science and human ingenuity are likely to overcome it,” said Mellors. “We hope that the antibodies we have discovered will contribute to that victory.”


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