Researchers find some covid-19 vaccines may increase risk of HIV infection


Top Line

Some of the Kovid-19 vaccines currently in development may increase the risk of acquiring HIV, a group of researchers warned the Lancet The Medical Journal Monday, potentially leading to an increase in infections as vaccines rolled out to vulnerable populations worldwide.

Key Facts

Researchers warned of a “cautionary tale” over a decade ago from attempts to create an HIV vaccine, where a promising vaccine candidate actually increased the risk of some men catching the virus.

The vaccine used a modified virus – called adenovirus 5 (Ad5) – as a vector for the transport of certain genetic substances of HIV in the body.

Exactly how the vaccine increased the risks of HIV transmission is unknown, but a conference organized by the National Institutes of Health recommended against further use of Ad5 as a vector in the HIV vaccine (Dr. Anthony Fauci called this post The recipient was the lead author of the paper.)

Ad5 is used as a vector in some Kovid-19 vaccines – Science Identifies four candidates who are currently conducting clinical trials in various countries of the world including the US, with two extensively underway in Phase 3 in Russia and Pakistan.

Researchers stressed the need to understand the role Ad5 could play in increasing HIV risks in vulnerable populations before developing and using vaccines, saying informed consent documents the risk of HIV acquisition on Ad5 ” Considerable literature “should reflect that. Vectors.

Main background

Many vaccines use modified viruses to carry material into the human body. Many use a modified adenovirus to do this, a virus that is usually harmless except for its ability to cause the common cold. Some key candidates for Johnson & Johnson and AstraZeneca’s Kovid-19 vaccine use adenoviruses as vectors. There is no evidence that those vectors increase the risk of HIV infection.

Serious sentiment

The authors stated that they became public because Ad5 vaccines for Kovid-19 could soon be tested in populations with high HIV prevalence. Lawrence Corey, one of the authors who now co-leads the Kovid-19 prevention network in the US that is testing vaccines on behalf of the NIH, reported Science If he was in a sub-Saharan African country with a high prevalence of HIV, “I don’t see why I would choose an Ad5 vector (vaccine) when there are many other alternative options.”

Further studies

Can some COVID-19 vaccines make people vulnerable to the AIDS virus? (Science)

Use of adenovirus type-5 weighted vaccines: a cautionary tale (Lancet)

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