Home / Health / The University of China is "surprised" by a researcher's report on the first human babies genetically edited by CRISPR

The University of China is "surprised" by a researcher's report on the first human babies genetically edited by CRISPR



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<p class = "canvas-atom canvas-text Mb (1.0em) Mb (0) – sm Mt (0.8em) – sm" type = "text" content = "It is not the usual way in which accredited scientists announce their advances in the world, but on Monday, Jiankui He released a video proclaiming that he had produced the first human babies in the world whose genomes were edited using the powerful technique called CRISPR. There was also previously talked to the Associated Press about his study, which he said resulted in twin girls born with the first genomes edited by man. "data-reactid =" 16 "> It is not the usual way that accredited scientists announce their advances to the world, but on Monday, Jiankui He published a video in which he proclaimed that he had produced the first human babies in the world whose genomes had been edited using the powerful technique called CRISPR, he had previously spoken with the Associated Press about his study, which says that it resulted in two twins born with the first genomes edited by man.

The report was received with concern and instant skepticism from the scientific community. His experiment altered the genomes of embryos produced through IVF; Therefore, your genetic changes will be passed on to future generations. In addition, most CRISPR experts are not convinced that the technology is ready, or safe, for the treatment of human beings.

<p class = "canvas-atom canvas-text Mb (1.0em) Mb (0) – sm Mt (0.8em) – sm" type = "text" content = "" Given the current state of the genome editing technology I am in favor of a moratorium on the implantation of edited embryos … until we first find a set of well-thought-out security requirements. " Feng Zhang, said one of the co-discoverers of CRISPR and the Broad Institute of MIT and Harvard, in a statement in response to the report. "Not only do I see this as risky, but I am also deeply concerned about the lack of transparency surrounding this test." "Data-reactid =" 18 ">" Given the current state of the genome editing technology, I am in favor of a moratorium on the implantation of edited embryos … until we find a set of well-thought-out security requirements. "Feng Zhang, one of the co-discoverers of CRISPR and the Broad Institute of MIT and Harvard, said in a statement. responding to the report. "Not only do I see this as risky, but I am also deeply concerned about the lack of transparency surrounding this trial."

<p class = "canvas-atom canvas-text Mb (1.0em) Mb (0) – sm Mt (0.8em) – sm" type = "text" content = "In 2015, prominent members of the scientific community are familiar with technology, including Zhang and another co-discoverer, Jennifer doudna from the University of California, Berkeley, agreed to voluntarily stop research on the use of CRISPR in human embryos because the safety and long-term consequences of the technology were too uncertain. Researchers support studies in which CRISPR is used to develop treatments that could affect cells that are not passed on to the next generation, that is, anything except the ovum and sperm, but claim that more research is needed before using CRISPR to make changes in the genomes. that can be carried out generation after generation. "data-reactid =" 19 "> In 2015, prominent members of the scientific community familiar with the technology, including Zhang and another co-discoverer, Jennifer Doudna of the University of California at Berkeley, agreed to voluntarily stop the investigation on the use of CRISPR in human embryos because the safety and long-term consequences of the technology were too uncertain.The researchers support studies in which CRISPR is used to develop treatments that could affect cells that are not transmitted to the next generation – that is, anything except ovules and sperm – but say that more research is needed before using CRISPR to make changes in the genomes that can be transported by a generation later.

<p class = "canvas-atom canvas-text Mb (1.0em) Mb (0) – sm Mt (0.8em) – sm" type = "text" content = "While editing the DNA of a human embryo is not currently allowed in the US, in 2017, an international committee of the National Academy of Sciences called for loosening the moratorium and Allowing CRISPR assays in human embryos., under strict supervision, to treat rare genetic diseases that can not be treated in any other way. In the USA UU., Officials approved CRISPR studies on human embryos in 2016, but those embryos will not be transplanted to create a pregnancy. These tests require the destruction of the embryos after a week, as the safety of the technology remains unclear. "Data-reactid =" 20 "> While in 2017 it is not allowed to edit the DNA of a human embryo in the USA, An international committee of the National Academy of Sciences called for loosening the moratorium and allowing CRISPR trials on human embryos, under strict supervision, to treat rare genetic diseases that can not be treated in any other way. In the UK, officials approved CRISPR studies in humans embryos in 2016, but those embryos will not be transplanted to create a pregnancy, but require the destruction of the embryos after a week, since the safety of the technology It remains unclear.

He, on the other hand, apparently has been ahead of the production of the first human babies born with CRISPR editing. He is on the faculty of the Southern University of Science and Technology in Shenzhen, China, but in a statement issued in response to He's videos, the university said he is out of work without pay from February 2018 to January 2021; The officials did not give a reason for the license.

"The University was deeply shocked by this event and took immediate steps to communicate with Dr. Jiankui He," the officials said in the statement. "The investigation was conducted off-campus and the University or the Department was not informed [to which He belongs]"The statement went on to state that the university" believes that the conduct of Dr. Jiankui He in the use of CRISPR / Cas9 to edit human embryos has seriously violated academic ethics and codes of conduct … The University will convene international experts to form an independent committee "Investigate this incident, and publicize the results."

<p class = "canvas-atom canvas-text Mb (1.0em) Mb (0) – sm Mt (0.8em) – sm" type = "text" content = "CRISPR, first described in 2012, provides scientists with the most accurate and effective way to edit the human genome by eliminating offensive mutations or genes and allowing the genome to repair itself or giving researchers the ability to insert new genetic material to correct disease genes. But studies suggest that controlling CRISPR in human cells remains a challenge; In some cases, CRISPR can cut off unintended parts of the genome. "data-reactid =" 23 "> CRISPR, first described in 2012, provides scientists with the most accurate and effective way to edit the human genome by eliminating mutations or genes offensive and allow the genome to repair itself or provide researchers with the ability to insert new genetic material to correct disease genes, however, studies suggest that control of CRISPR in human cells remains a challenge, in some In some cases, CRISPR can cut off unintended parts of the genome.

In his promotional video, he describes the goal of the CCR5 gene, which helps the HIV virus enter healthy human cells. He worked with seven heterosexual couples in which the male partner was HIV positive and the women HIV negative. After the couples produced embryos through IVF, they used CRISPR to cut the CCR5 gene, disabling it in the hope of making the embryos less vulnerable to HIV infection. He states that of 22 embryos, 16 showed signs of success in the CRISPR edition, and 11 were implanted, which resulted in a single pregnancy with twin girls who were born in November. A twin, according to He tests, showed signs that the two copies of the CCR5 gene he inherited (one from his mother and one from his father) were successfully altered, while the other showed that a version of the gene he inherited was altered

The so-called mosaicism, in which some, but not all cells of the embryo are altered, is worrisome, since in this case, this would mean that the girl is not completely protected from HIV infection like her sister. That is one of the reasons why researchers are concerned about the report. Normally, these scientific milestones are reported in complete scientific journals with detailed descriptions of how the researcher accomplished the feat along with the data that supports his claims. Without such documentation, it is impossible to verify whether the girls actually showed a successful CRISPR edition or not.

<p class = "canvas-atom canvas-text Mb (1.0em) Mb (0) – sm Mt (0.8em) – sm" type = "text" content = "He, who created two companies based on his studies, has planned to present its conclusions in the Second International Summit on the Human Genome Edition, and will undoubtedly be the target of numerous questions from the leading gene publishers who attended. "data-reactid =" 28 "> He, who created two companies based on his studies, plans to present his findings at the Second International Summit on the edition of the human genome, and will undoubtedly be the target of numerous questions from leading scientists in editing genes that will attend.

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