People who regularly use acid reflux drugs are 24% more likely to develop type 2 diabetes.


People who regularly use acid reflux drugs are 24% more likely to develop type 2 diabetes, the study found

  • Proton pump inhibitors (PPIs), such as Prilosec, help to lower stomach acid production and treat indigestion, ulcers, acid reflux and heartburn.
  • The absolute risk of developing type 2 diabetes, if routinely used PPIs, was 7.44 out of 1,000 compared to 4.32 out of 1,000 people for non-PPI users.
  • After accounting for other factors, such as high cholesterol, regular PPI-use was associated with a 24% increased risk of being diagnosed with diabetes
  • Up to two years of use were associated with an increased risk of 5% and an increased risk of 26% for more than two years.

People who regularly use acid reflux medications have an increased risk of developing type 2 diabetes, a new study suggests.

Researchers found that those taking proton pump inhibitors, identified by brand names such as Prilosec and Nexium, are nearly twice as likely to detect blood sugar disease.

What’s more, the longer a patient takes medication regularly, the higher the risk of diabetes.

The team at Sun Yat-sen University’s seventh affiliated hospital in Shenzhen, China, says that people on these drugs for more than two years should have their blood sugar checked regularly for diabetes.

Proton pump inhibitors (PPIs), such as Prilosec (pictured) and Nexium, reduce acid production in the stomach to treat conditions like indigestion

A new study found that regular use of proton pump inhibitors, such as prilosec (above), was associated with a 24% increased risk of diagnosis of type 2 diabetes.

Proton pump inhibitors (PPIs) work by blocking an enzyme in the stomach wall that produces acid.

It helps in treating ulcers or pre-existing ulcers, as well as treating acid reflux and recurrent heartburn.

What are PPIs (proton pump inhibitors)?

Proton pump inhibitors (PPIs) reduce acid production by blocking enzymes in the stomach wall that produce acids.

The acid is essential for the formation of most ulcers in the esophagus, stomach, and duodenum, and acid deficiency with PPIs prevents ulcers and allows any ulcers present in the esophagus, stomach, and duodenum to heal.

Proton pump inhibitors are used for the prevention and treatment of acid-related conditions such as:

  • Esophageal duodenum and stomach ulcers
  • NSAID-Related Ulcers
  • Ulcer
  • Gastroesophageal reflux disease (GERD)
  • Zollinger-Ellison syndrome

There are not many differences between PPIs, although some PPIs may have a longer lasting effect; Therefore, they can be taken less frequently.

The most common side effects of proton pump inhibitors are:

  • head ache
  • Diarrhea
  • Constipation
  • stomach ache
  • fever
  • Vomiting
  • Nausea
  • Rash

Nevertheless, proton pump inhibitors are generally well tolerated.

The source: Medicinenet

PPIs are slightly different than Zentac, such as histamine-H2-receptor-antagonists (H2 blockers), which specifically reduce the stomach acid released in the evening.

Approximately 15 million American adults use PPIs every year.

Previous research has linked long-term PPI-use to an increased risk of many conditions such as kidney disease and stomach cancer.

For the study published in the journal Gut, the team looked at approximately 205,000 participants from three national studies: the US Nurses Health Study (NHS), the NHS II, and the Health Professional Follow-up Study (HPFS).

The NHS and NHS II examined risk factors for major chronic diseases in women, while HPFS did the same for men.

Volunteers were asked if they regularly use defined PPIs at least twice per week per week.

During the study period, more than 10,000 participants developed type 2 diabetes.

Prior to accounting for external factors, the risk of type 2 diabetes diagnosis was among PPI users, as there were 7.44 out of 1,000 compared to 4.32 out of 1,000 who did not take PPI.

After adjusting for other factors such as high cholesterol and high blood pressure, regular PPI users were 24 percent more likely to develop diabetes than those who did not take them.

Taking these drugs for a long time increased the risk. Up to two years of use were associated with a five percent increased risk and use over two years was associated with a 26 percent increased risk.

Once a person stopped taking PPIs, the risk decreased with the passage of time.

Researchers said that factors such as age, sex, and family history of diabetes among PPI users did not affect diabetes risk, but it was higher in users whose blood pressure was normal and weight was normal.

“Due to widespread use, the total number of diabetes cases associated with PPI-use may be considerable,” the authors wrote.

‘Investigation of abnormal blood sugar and type 2 diabetes is recommended for patients who have to receive long-term PPI treatment.’

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