Kovid-19 vaccines leave pregnant women in a quartet

Doctors say that this answer depends on the woman’s risk of Kovid-19 and her underlying health issues, but there is not yet enough data to make a definitive recommendation. In the meantime, guidance varies from health agencies.

“What is the risk to my child if I get the vaccine?” That empty space, that data-free area that does not know what the effect will be, is really worrying, ”said Jennifer Levey, a 40-year-old cardiologist at the University of Pennsylvania Hospital, which is due on March 21.

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Dr. The dilemma faced by optimistic mothers such as Levi, who decided to skip vaccination for now and rely on masking and other precautions, highlighted a gap in the course of their evolving development of Kovade-19 vaccines: pregnant women. Was tested in

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The companies behind the two Kovid-19 vaccines authorized in the US did not enroll pregnant women in late-stage trials to find out if the shots worked safely.

Absent hard data, the US Center for Disease Control and Prevention, the American College of Obstetricians and Gynecologists and the Society for Maternal-Fetal Medicine say pregnant people should decide for themselves by encouraging interaction with doctors.

Dr. Levi, who is scheduled to give birth on March 21, keeps her 3-year-old son in their Philadelphia home.


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Meanwhile, the World Health Organization, citing insufficient data, has generally advised against shots in pregnancy, excluding health care workers such as high-risk individuals or people with certain health issues. But on Friday, the WHO also stated on its website that “we have no specific reason to believe that there will be specific risks that will outweigh the benefits of vaccination for pregnant women.”

Michele Allowitz, an obstetrician and gynecologist and director of the Center for Obstetrics and Child Health Research at the University of Michigan, said she leaves her patients’ choices after discussing potential benefits and risks.

Dr. Elowitz said that expectant mothers are more likely to have severe cases of Kovid-19 than pregnant women and require preterm delivery, if they have the disease. The vaccine can help reduce the risks. Also, some vaccines for other infections have been shown to be safe in pregnancy and to provide protection to mother and child.

Most experts say they do not anticipate any issues, depending on how mRNA vaccines work. Yet scientists do not yet know whether the mRNA vaccine can cross the placenta, and if it can, scientists do not know if it will harm fetal, maternal and fetal health experts. They say that such vaccines have never been used in pregnancy. Pfizer and Modern Vaccines use a gene-based technique called Messenger RNA, which was never cleaned up for use until the epidemic.

Uncertainty makes the choice to vaccinate mothers very challenging, expected.

“It was a difficult decision,” said 37-year-old Brenda Manning, who is currently eligible to receive the vaccine in Dallas, where she lives.

Ms. Manning has limited exposure to Kovid-19 because she is a stay-at-home mother whose husband works from home. Yet her pregnancy and high blood pressure make her at greater risk of having a severe case of Kovid-19, should she receive it.

After weighing her options, Ms. Manning decided to sign up for the vaccine, although she has not been given a date for her first dose. If she gets an appointment before the 14 February date, she can make a final call.

“If I’m called before doing this [the baby] She says, I will fix the time of the game. “And if I haven’t had the opportunity to get the vaccine before then, my answer is.”

Brenda Manning in Texas with her husband and son. She is at a greater risk of a serious case due to pregnancy and high blood pressure.


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According to expected mothers, how doctors can handle this matter. Many said that their doctors drove them through the risks and benefits before they left judgment on them. Other women said their doctors encouraged vaccination after those conversations.

Some 39% of pregnant women surveyed by the University of California, San Diego and pregnancy-counseling group MotherToBaby said that if they had it available, they would not get the Kovid-19 vaccine, while 25% said they would not get a breastfeeding. Commentary while doing.

Thirteen percent said they would not receive the vaccine, even though according to the survey, which began in October and continues.

Christina Chambers, a professor of pediatrics at the University of California, San Diego, who is helping to lead the survey as part of a study of how Kovid-19 and vaccines affect pregnancy and breastfeeding, said women Due to lack of information there is inhibition.

Dr. Chambers said she hopes more pregnant women will become comfortable with vaccinations as the rollout continues.

Delays in establishing safety of Kovid-19 vaccines in pregnant women and embryos that partially test animals have stems from lags, said Ruth Fadden, founder of the John Hapkins Burman Institute of Bioethics, who helped lead the Prevent project , Which advocates the inclusion of pregnant women. In the development of vaccines during the epidemic.

The US Food and Drug Administration recommends animal studies in pregnant women before researchers test the vaccine.

Modern states that its vaccine had no adverse effect on reproduction or development during testing in mice. The company plans to set up a registry to vaccinate mothers who are pregnant and to hire their infants.

Pfizer says it has finished studying animals and submitted data to the FDA. The European Medical Agency said animal studies found that Pfizer’s vaccine did not have a detrimental effect on reproduction or development. Pfizer says it will begin a maternal vaccine study in the first half of 2021.

Pfizer and Modern say they are tracking people who became pregnant after vaccination, as well as any pregnant people who slipped from pre-vaccination screening during the trial.

Britain did not initially include women who were pregnant or soon to become pregnant in their vaccine rollout in December. Public Health England updated its guidance in January, however, stating that vaccination may be particularly important for people who are highly exposed to the virus or have some underlying high-risk health condition. In those cases, women can choose whether to receive the vaccine after discussing it with their doctor or nurse, the agency said.

In January, the Israeli Ministry of Health updated its guidance to recommend vaccines for pregnant women, particularly for pre-existing medical conditions and for those who are at a much greater risk to the public.

President Biden announced to boost the supply of Pfizer and Modern Vaccines sent to the states for the next three weeks and to buy enough additional supplements to vaccinate most of America’s population by the end of summer. Photo: Doug Mills / Getty Images

write to Sara Toy at [email protected] and Laura Cooper at [email protected]

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