JUUL electronic cigarettes linked to cell damage.


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Little is known about the possible health effects of JUUL electronic cigarette products that have recently increased in popularity, especially among teenagers. The Food and Drug Administration (FDA), or FDA, has a growing concern about this increase in use because these electronic cigarettes supply nicotine, a highly addictive stimulant, with potential to affect the adolescent brain in developing.

A research team led by Prue Talbot, a professor in the Department of Molecular, Cellular and Systems Biology at the University of California at Riverside, and James F. Pankow, professor of chemistry and civil and environmental engineering at Portland State University, Oregon has now discovered that nicotine concentrations are higher in JUUL electronic cigarettes than in any of the hundreds of other electronic cigarette products badyzed by the team.

"Nicotine concentrations are high enough to be cytotoxic, or toxic to living cells, when tested in vitro with cultured respiratory system cells," said Talbot, director of the UCR Stem Cell Center. "JUUL is the only product of electronic cigarettes that we find with nicotine concentrations high enough to be toxic in standard cytotoxicity tests, a big concern is that its use will mean a new generation of teenagers to nicotine."

The results of the study appear in Chemical research in toxicology.

JUUL e-cigarettes are manufactured by JUUL Labs, an electronic cigarette company. The use of JUUL is widespread among high school and high school students.

The research team made a second finding: although each flavor of the JUUL capsule (eight different flavors are available) has relatively few flavor chemicals, several of these chemicals are present in high concentrations.

"Some JUUL flavor pods have sufficiently high concentrations of flavor chemicals that can make them attractive to young people," said Pankow. "We still have to determine if JUUL products will lead to adverse health effects with chronic use."

"We found that some flavor chemicals, such as ethyl maltol, also correlate with cytotoxicity, but nicotine seems to be the most potent chemical in JUUL products, due to its high concentration," Talbot said.

The nicotine found in JUUL products is currently, on average, about 61 milligrams per milliliter of liquid in pods, equivalent to more than one pack of conventional cigarettes.

Talbot hopes that the FDA will limit the allowable concentration of nicotine in electronic cigarette products.

"The FDA is trying to avoid JUUL sales to those under 21, but these products still find their way into high schools," he said. "Our data reinforce the need to prevent adolescents from using products with these extremely high nicotine concentrations."

"Despite the commercials that promote electronic cigarettes and JUUL products as smoking cessation tools, studies have shown that the increasing use of these products among youth and adolescents can serve as a gateway to the consumption of tobacco. tobacco and other substances, "said Julie Chobdee, coordinator of the UCR Wellness Program, who did not participate in the study.

Talbot explained that various flavor chemicals present in electronic cigarette refill fluids, such as diacetyl, cinnamaldehyde, menthol and ethyl vanillin, are popularly found in sweet, creamy and fruity / citrus e-liquids.

"Depending on their concentrations in the products, these chemicals can cause various toxic effects, as has been noted in case reports and laboratory studies," he said. "For example, diacetyl is a flavoring ingredient commonly found in popcorn, but inhaling diacetyl can cause a serious lung disease called bronchiolitis obliterans."

A study measures the free form of nicotine in electronic cigarettes.

More information:
Esther E Omaiye et al, Products of electronic cigarettes with high nicotine content: the toxicity of JUUL fluids and aerosols correlates strongly with nicotine and some chemical concentrations of flavor. Chemical research in toxicology (2019). DOI: 10.1021 / acs.chemrestox.8b00381

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University of California – Riverside

JUUL Electronic Cigarettes Linked to Cell Damage (2019, April 9)
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