Kimmel had spoken in tears about Billy's birth on April 21 with a serious heart problem and used it as a reason to ensure that medical care in this country is affordable for everyone.
The newborn had open heart surgery a few days after his birth and this week he had a second successful surgery.
Kimmel has used his experience as the father of a sick child to become one of the most prominent advocates in the health care debate.
His wife is now reflecting on why he felt the need to immerse himself in the political hotbed.
"Our family has excellent medical care, I had nothing to gain from that," he said. "He did it for the other people we met at that hospital, he came home that night, and I just hugged him and I did not let him go."
McNearney said the response has been overwhelming with strangers still coming and thanking Kimmel for her monologue.
But there have also been violent reactions, he said, with accusations that they "politicized" his baby's health crisis.
"We took a personal experience and shared it with the world, and then it happened that this was happening while people were trying to take care of children like ours," said McNearney. "People were sending letters to our house, attacking us both on Twitter, saying things like we deserve this and we are terrible people."
And although she said she is not thrilled with the lack of privacy that comes with her being so public about her children's health, McNearney feels it's worthwhile to help others.
He also reiterated his pride for Kimmel.
"I really want the day to come when I can count [Billy] on all this," he said. "I want to be the one to tell Billy what his father did for him"