Have you ever seen your hands? I mean Actually See your hands?
You might think that you have, but as a classic above Doonesbury Cartoons Meaning, people who are high Cannabis Earthly objects can be experienced to be more attractive than normal.
How is it Plant This is the first time that the Tibetan plateau can now change humans’ perception of reality. The secretory is located in a class of compounds called cannabinoids. While cannabis plants are known to produce the least 140 The type of cannabinoids is the one largely responsible for the high feeling effects. It is called tetrahydrocannabinol, or THC.
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When a person drinks cannabis or drinks cannabis, THC “goes into your lungs and gets absorbed into the blood …”, Daniele Piomelli, Anatomy and Neurobiology, Biological Chemistry, and University of California, Irvine According to a professor at the School of Medicine. . Edibles travel a little longer through the liver, where enzymes turn THC into a different compound, which takes a little longer to affect people’s perception of reality.
Pocily told Live Science that THC had “reached a very high level”. Within 20 minutes, the circulatory system is transporting THC molecules to every tissue in the body, including the brain, where it can alter neurochemistry.
“From the lungs, it’s a very direct shot to the brain,” according to Kelly Drew, a professor of chemistry and biochemistry at the University of Alaska Fairbanks.
Molecules of THC that pass through the blood-brain barrier will find that they fit snugly into receptors that normally receive compounds called endocannabinoids, which the body produces itself. These receptors are part of the endomenabinoid system, which is involved in a number of tasks, including stress, food intake, metabolism, and pain, according to Paumeli, who also directs the Center for the Study of Cannabis at UC Iredine.
“The endocannabinoid system is the most widespread, diffuse and important modular system in the brain because it controls the release of pretty much every neurotransmitter,” Piomelli said. Neurotransmitters are the molecules that brain cells, or neurons, use to communicate with each other. One neuron sends a message to the next by releasing neurotransmitters, such as dopamine or serotonin, into an infinitimal gap that separates the next neuron from the next. Gap is called Synapse.
The neuron at the receiving end of the synapse is called a postsynaptic neuron, and it “decides whether to fire based on the received input,” Drew told Live Science. These neural signals cascade through complex circuits of neural connections that act on a tremendous scale; There almost 85 billion Neurons in the brain and the more 100 trillion connections from them.
The presynaptic neuron sends the neurotransmitter to the postsynaptic neuron after synapse, Piomelli said. But presynaptic neurons can also receive information. When a postsynaptic neuron has been fired, it can send a message to the synaptap that says, “The neuron I came from has been activated,” stop sending neurotransmitters, Piomelli said. It sends this “stop” message in the form of endocannabinoids that bind a receptor called cannabinoid 1 (CB1).
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“Like a sledgehammer”
When THC enters the brain, the molecules spread to the synapse, where they “activate CB1 receptors,” Drew said. THC does not cause the most extreme response possible Like some synthetic cannabinoids As K2 or spice, but it “turns up the volume” and raises the possibility that the presynaptic neuron affecting it will temporarily stop sending neurotransmitters, she said.
“High is a very simple phenomenon, Piomelli said. THC comes in like a sledgehammer,” with the signal to postseptic neurons not to flood the endocannabinoid system. When presynaptic neurons throughout the brain receive memos to stop sending neurotransmitters, this. Alters the normal flow of information between neurons and gives a higher result.
Scientists have yet to understand what exactly it is during this excitement.
This is because in the US, legal restrictions make it difficult to study cannabis. But out of what the researchers have gathered so far, THC temporarily “unplugs” the default mode network. It is the brain network that allows us to think and think about the past and the future. When our minds are focused on a specific task, we pacify this network so that our executive can control the task.
There is evidence that THC has a significant effect on the network, but researchers are not sure how this happens. The entire brain has cannabinoid receptors, including “those areas that are the major nodes. [default mode network], “Piomelli said. It could be that” THC becomes inactive [default mode network] By combining with those receptors, “but it is also possible that THC calms the network through an indirect effect that includes cannabinoid receptors in other brain regions.” ”
Scientists are still working to find the mechanisms that result in a person feeling high, but some reason to think this effect on the default mode network is an important piece of the puzzle.
Unplugging the default mode network “takes us into a mental space where the function of the things we experience are less important than the things we own: our hands are no longer just something we touch or grab Use for, but rather do something with intrinsic existence and intrinsic value “,” said Piomelli. Psychedelics, such as mushrooms containing LSD or dried Psilocybin, do the same thing.
However, people may experience highness differently. Piomelli said, “The feeling of becoming fascinated and ‘connected’ with the common things we see and use every day is not universal, but it happens, especially when using high doses of THC-containing cannabis Is done, ”Piomelli said.
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THC does not just affect the default mode network. According to a 2017 study in the journal Nature, it can also flood the brain with dopamine, a reward reward signal, in the short term. (In the long run, it can blunt the effects of dopamine, the study found.) Which may, in part, explain some of the euphoria associated with high medications, and cannabis use in other drug companies. Is what people use to feel happy.
“Every drug that has beneficial properties affects that system,” Drew said.
The effects of high or smoking emanating from cannabis usually last for a few hours, although it can take edibles almost longer to affect users. While cannabis was not a dangerous substance Made in the 20th century, It comes with some risks. For one, while cannabis is legal for recreational and medical use in some states, it is still illegal in many parts of the country.
It is also important to note that cannabis is a powerful medicinal substance. Cannabis can cross the placenta, so Pregnant people should avoid it. “And heavy use in teenage years can be problematic,” Piomelli said. For example, cannabis – and especially synthetic cannabinoids like spices – can. Exaggerated psychosis. “People who are at risk for it should not smoke it,” Drew said.
Finally, cannabis affects the ability to drive, especially in topical users. Drew warns that people should Non run Three hours after smoking.
Eventually, THC will leave the brain; The blood flow that brings THC to the brain will carry it to the liver, where it will be destroyed and expelled into urine.
And you’re not going to believe it, but your hands – they were the same the whole time.
Originally published on Live Science.