How COVID-19 attacks the brain

This is the “invasion of physical snatchers” at the cellular level.

A new Yale University study on how the coronovirus affects the nervous system showed that the viral attacker attacks the brain to copy itself to take its victim’s brain cells, while a Also cuts off all available oxygen, thus suffocating nearby. Cells.

Their findings, which await peer review on BioRXiv, add evidence to claim that the brain is on a growing list of COVID-19 vulnerabilities, including the lungs, kidneys, liver, intestines and blood vessels. Huh.

“If the brain becomes infected, it can have a fatal outcome,” Akiko Iwasaki, a pathologist and lead researcher at Yale University, told the New York Times.

Coronavirus is a disease of the whole body. Broadly speaking, doctors have seen its long-term respiratory symptoms, such as cough, troubled breathing, and pneumonia. Soon, he added more perplexing issues: gastrointestinal discomfort and diarrhea; Loss of taste and smell; Chest pain and arrhythmias; Brain fog and confusion.

In addition to the patient’s anecdote, “We hadn’t really seen much evidence that the virus could infect the brain, even though we knew it was a potential possibility,” Dr. Michael Zandi, consultant neurologist at the National Hospital of University College London for Neurology and Neurosurgery, told the Times. In July, Drs. Zandi’s team published a report in Oxford University’s journal Brain, in which they saw and heard patients suffering from neurologic effects after the COVID-19 diagnosis.

brain scan
A study published in July in the Oxford University journal Brain Brain Scan showed coronovirus patients.Ross W. Peterson et al.

“this [new] The data provides just a little bit of evidence that it can certainly do, ”he said.

Unlike other diseases such as Zika, which cause our immune system to turn on our own brain tissue, the coronovirus works by entering a cell through a protein on its surface, called ACE2. Then usurps cellular components to speed up viral production. Throughout time, it deprives other cells of oxygen along the way.

“It’s like a silent infection,” Dr. Said Iwasaki, whose team observed brain tissue in dead COVID-19 patients, mice, and cells developed in the laboratory. “This virus has a lot of theft mechanisms.”

A neuroscientist from the University of California, San Diego, Dr. Eilson Muotri, who studied zika in the past, noted that the presence of coronovirus severely hindered between neurons. “The day after infection, and we already see a dramatic decrease in the amount of synapses,” Dr. Muotri said. “We do not yet know whether it is reversible or not.”

Researchers now believe that coronovirus brain infections can be more fatal than being centralized in the lungs based on mouse experiments that compare results when centered within one organ or another. Brain-infected specimens lost weight and died within six days. None of these side effects were seen in the lung group.

Unfortunately, it is not yet possible to predict the route of cellular infiltrators. In addition, 40% to 60% of patients who claim to suffer brain and psychiatric symptoms may be related to widespread inflammation due to the body’s immune response to COVID-19, according to a recent study by The Lancet Can.

“There is no need for brain cells to be self-infected. [some brain-related symptoms] To happen, “Dr. Zandi said.

“Different groups of patients can be affected in different ways,” he said. “It is very possible that you will see a combination of both.”


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