Honeybee venom may kill invasive breast cancer cells: study

If his significant contribution to agriculture was not enough to convince humans to save bees, perhaps it would help sweeten the pot.

Researchers in Western Australia have discovered that the toxin from honeybees is a powerful anti-tumor agent, which in mice subjects is a surprisingly invasive destruction of breast cancer cells.

The prospective groundbreaking study, published in the NPJ Precision Oncology Journal, was carried out by scientists at the Harry Perkins Institute of Medical Research in Perth.

“We found that the toxin from honeybees is actually quite effective in killing some of the invasive breast cancer cells, which are not harmful to normal cells,” said lead researcher Sierra Duffy.

Duffy told the Australian Broadcasting Corporation that he expects 10-15% of women with triple-negative breast cancer to live up to the promise – meaning patients whose disease includes all three common cancer-drug receptors, including the hormone estrogen Progesterone, as well as human epidermal growth factor, called HER2, explain the US Center for Disease Control and Prior. Typically, these receptors can aid doctors’ fight against the development of tumors through the use of targeted therapy, which helps patients overcome the full-body cracks of chemotherapy. According to the American Cancer Society, the five-year survival rate for the most progressive cases can be as low as 11%.

However, new studies have revealed the exact proportion of toxin that can kill triple-negative as well as HER2-positive, breast cancer cells.

These are no bees, Australian researchers claim. Perth bees are “some of the healthiest in the world”, said Duffy, who complemented the local hive population with bees from Ireland and England. To take their nectar, the bees are driven to sleep by carbon dioxide, then preserved on ice, after which the toxin is extracted and injected directly into the tumor.

But instead of suggesting a large-scale harvesting of Hahnies’ venom, Duffy’s team found that the toxin contained a known chemical element of a peptide called melittin – the component, in fact, that occurs after the bee stings Is responsible for the pain – had the same anticancer effect.

Duffley stated that melittin actually enters the surface, or plasma membrane, and creates pores or pores and this causes the cell to die. as docetaxel. When combined, she explained, melatonin would first puncture the cancerous membrane, allowing better penetration of chemo into the malignant mass.

Scientists also observed that the benefits of melittin extend beyond the goal of future reproduction and future inhibition of triple-negative and HER2 cells cells.

“We found that it was interfering with the key message or cancer-signaling pathway that are fundamental for the growth and replication of cancer cells,” she said.

Globally, honeybees have long been under threat, despite efforts to boost their population. Nevertheless, bee products have been used for cosmetic and medicinal purposes for thousands of years for their anti-inflammatory, anti-bacterial, anti-fungal, anti-viral, and antioxidant properties.

The Australian Broadcasting Corporation reported that Duffy was reticent to call it a “success”.

“There’s a long way to go in how we deliver it into the body and, you know, looking at the toxicity and the maximum tolerated dose, before it goes ahead,” she said.


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