The heaviest man in the world undergoes life-saving bypass surgery
. A new study showed that a high-fat diet can help you lose weight. The researchers discovered a method in which altering the signaling system of the Hedgehog route resulted in the suppression of obesity.
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A team of researchers has discovered a method that allows mice to eat fat to the content of their heart without being obese. The technique could, according to reports, treat and prevent humans from becoming obese in the future.
Scientists manipulated a signaling system called Hedgehog, which is involved in the development of cells throughout the body. The team at the University of Washington School of Medicine managed to contain obesity in mice, indicating that in the future a similar pharmaceutical route could be developed for humans.
The researchers cultured mice with genes that would activate the Hedgehog pathway in their fat cells when the mice consumed a large amount of fat. The result of the research showed that although the mice with that diet did not become extremely obese, the laboratory mice that did not have the special genes became fat.
By stimulating Hedgehog and the bound proteins in fat cells, the researchers avoided the fat of the mice the cells accumulate and store droplets of fat. The researchers believe that if they can discover strategies to carefully target the fat cells, activating the pathway could be useful to combat obesity.
The findings show that the Hedgehog pathway does not allow the cell to grow more than a certain size. He also maintained low blood sugar levels for the treated mice.
"Fat gain is mainly due to the increase in the size of fat cells," said researcher Fanxin Long. "Every fat cell grows larger so that it can contain larger fat drops, we gain weight mainly because fat cells grow, instead of having more fat cells."
Hedgeway Pathway For Humans
Researchers believe that more research will be required for the process to be successful in humans. However, it could result in a new therapy to treat obesity. Long added that the mice used in the study consumed a diet high in fat but did not gain weight. In the case of people, excess fat leads to obesity.
Long also said that replicating the findings for humans can be complicated and that any drug that activates the pathway must be meticulously targeted to avoid possible adverse effects. Certain cancers have been linked to excess Hedgehog activity; however, because it is believed that the system works in the same way in mice and humans, it might be possible to direct it to fat tissue as an obesity treatment.
More than one third of the adult population of the United States. UU It is obese. The estimated annual medical costs for obesity are more than $ 147 billion in the country. Obese people are at increased risk of cancer, diabetes, heart attack and stroke.
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