According to a study published in the journal Cell Stem Cell, people who consume a high cholesterol diet may have an increased risk of colon cancer. Scientists discovered that diets rich in cholesterol can increase the rate of growth of the cancerous tumor by up to 100 times. It was discovered that by increasing the cholesterol levels of the mice, the intestinal stem cells were dividing more rapidly, allowing the tumors to form 100 times faster. The study has identified a molecular pathway that could serve as a new pharmacological target for the treatment of colon cancer.
"We were excited to discover that cholesterol influences the growth of stem cells in the intestines, which in turn accelerates the rate of tumor formation by more than 1
"While the connection between dietary cholesterol and colon cancer is well established, no one has previously explained the mechanism behind it," Tontonoz said.
For the study, scientists increased cholesterol in intestinal stem cells in some of the mice by introducing more of the substance into their diets.
In others, the researchers altered a gene that regulates phospholipids. , the main type of fat in cell membranes that stimulated cells to produce more cholesterol on their own. The ability of stem cells to multiply increased in both groups.
As animal cholesterol levels increased, their cells divided more rapidly, causing the tissue lining their guts to expand and their intestines to lengthen. These changes significantly accelerated the rate of tumor formation in their colon.
With PTI entries