Genes in men’s brain regulate sex drive, study finds


Scientists have discovered a gene in the brain that regulates sexual desire in men – and can be used to target treatments for male sex addiction

  • An enzyme called aromatase converts testosterone into estrogen in men’s brains.
  • Researchers have also identified a single gene that produces this enzyme.
  • The process of converting testosterone to estrogen builds the male sex drive.

A gene has been discovered in the brain that regulates a man’s sexual desire, paving the way for new treatments for sex addiction and dysfunction.

The gene regulates an enzyme, called aromatase, that is responsible for converting testosterone into estrogen in the brain, which conducts male sexual activity.

Estrogen is commonly known as the female sex hormone, but it requires a high level to drive libido, and is required for erectile function.

A man’s sex drive plummets, without creating estrogen from testosterone.

Researchers at Northwestern University found that the scent is produced by a single gene, called CY19a1, which opens up potential pathways to target the enzyme.

By successfully isolating the genes responsible for making enzymes, researchers hope to develop drugs to treat male sex addiction and low libido.

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A Northwestern University study investigated the role of aromatase in the brain and found that the enzyme converts testosterone into estrogen. This process is important for esex drives (stock)

The role of aromatase in the brain has been the subject of much research, scientists have struggled to understand its purpose.

The discovery of the gene responsible for the creation of an enzyme that converts testosterone into estrogen is a major breakthrough.

Senior writer at Northwestern University, Drs. This is the first significant discovery to explain how testosterone stimulates sexual desire, said Serder Bulun.

‘For the first time, we have conclusively demonstrated that the conversion of testosterone to estrogen in the brain is important for maintaining full sexual function or desire in men. Aromatase Drive ‘

The researchers removed the Cyp19a1 gene from the brains of male laboratory mice and placed them in cages with a female mouse.

Later sexual activity was eroded in half, while testosterone levels in rodents were higher than normal.

The inability to convert hormones from testosterone to estrogen had a clear effect on sexual desire.

Converting testosterone to estrogen requires a high level of libido to drive and is necessary for erectile function.  Without it, a man's sex drive is heartless.  Researchers also found that aromatase is produced by a single gene, called Cyp19a1 (stock)

Converting testosterone into estrogen requires high levels of libido to drive and is necessary for erectile function. Without it, a man’s sex drive is heartless. Researchers also found that aromatase is produced by a single gene, called Cyp19a1 (stock)

When flirting, women seek seriousness and maturity, but men seek beauty

The secret to successful flirting still lies in appearance rather than corny chat lines – but women also like intelligence and tenderness in a man, a study found.

Experts in Cyprus surveyed more than 800 volunteers – finding that both men and women come for people who are good-looking, well-dressed and attractive.

Allegedly men are seen as particularly good catches if their appearance and what they said were officials of intelligence and wealth.

Researchers also found that the gentle approach worked best – with an adventurer who was polite, respectful and ‘did not move too fast’ because of the possibility of being more successful.

The findings can help counselors and psychologists deal with clients who have confidence issues, or problems with social interaction.

‘Male mice partially lost interest in sex,’ co-author Dr. Hong Zhao said.

‘Estrogen is an enzyme important for estrogen production. Estrogen acts in men and women.

‘Testosterone has to be converted to estrogen to increase sexual desire in men.’

Aromatase deficiency is very rare in humans, but such cases have been reported. These men suffer from long-term testosterone levels.

While undergoing estrogen therapy, aromatase-deficient men reported significant improvement in the frequency of sexual activity.

However, the knock-on implications of this latest study extend far beyond aromatase-deficient men and may help modify sexual desire in large groups of men.

For example, many men suffer from low sexual desire, which is medically known as hypoactive sexual desire disorder.

This can be brought about by some medications, including a group of antidepressants known as SSRIs.

If drugs can be manufactured that target the aromatase enzyme in the brain, it can increase sexual desire, researchers say.

At the other end of the scale, it can also be used to deal with compulsive sexual desire.

Existing treatments have serious side effects but new selective drugs can avoid this.

The full findings have been published in the journal Endocrinology.

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