Experimental peanut allergy patch exhibits promise


Credit: Daniele Pellati/public area

An experimental patch that delivers a excessive dose of peanut protein has proven promise in lowering allergic reactions in kids and adults, researchers stated on Tuesday.

About two % of US kids are allergic to peanuts and should keep away from them altogether.

Peanut allergic reactions are on the rise, and are the most typical reason for extreme and deadly meals reactions within the United States, based on researchers.

The research printed within the Journal of the American Medical Association (JAMA) enrolled 221 kids and adults who’re allergic to peanuts.

Participants had been randomly badigned to a few teams, every of which wore a Viaskin Peanut pores and skin patch in several doses. A fourth group acquired a placebo.

The trial, generally known as section two, was designed to check which dose was greatest, and the way nicely it will work over a yr.

The highest dose examined, 250 micrograms, was handiest, and appeared to badist half the sufferers who wore it. The placebo patch helped one-quarter of wearers.

Patients had been thought-about “responders” in the event that they took with out incident both 1,000 mg or extra of peanut protein, or 10 instances the pretreatment quantity of peanuts.

But since there have been solely 28 sufferers within the 250-microgram patch group, a bigger research is required to higher perceive how nicely the patch may work.

“The sample size of each treatment group was relatively small,” stated the research led by Hugh Sampson of the Icahn School of Medicine at Mount Sinai, New York.

An additional trial—generally known as section three and which goals to flesh out extra extensively how the patch works—has been initiated in kids aged 4 to 11 utilizing the 250-microgram patch, based on the report.

In January, the National Institute of Allergy and Infectious Diseases (NIAID) urged dad and mom to feed infants peanut-containing meals starting on the age of 4 months to 5 years.

This observe reduces by 81 % the danger of peanut allergy amongst infants deemed at excessive danger as a result of they already had extreme eczema, egg allergy or each, the company stated.

Explore additional:
Skin patch exhibits promise in easing peanut allergy

More info:
Hugh A. Sampson et al. Effect of Varying Doses of Epicutaneous Immunotherapy vs Placebo on Reaction to Peanut Protein Exposure Among Patients With Peanut Sensitivity, JAMA (2017). DOI: 10.1001/jama.2017.16591

Journal reference:
Journal of the American Medical Association

© 2017 AFP

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