Diabetes Success: Scientists believe that diabetes can develop before birth


Experts previously thought that neonatal diabetes develops in infants under six months of age, which is caused by a mutation of insulin-producing cells. Since the two versions of the disease require different treatments, it is important that patients receive the correct diagnosis. The findings may lead to diabetes – and lead to new treatments.

Researchers from the UK and the US studied 166 children with diabetes who had a genetic mutation that could explain their condition before six months. They found that the youth suffered from a type of immune attack that occurs with type 1 diabetes that destroys insulin-producing cells.

Infants had a high genetic risk of type 1 and low insulin-producing capacity. Dr. of the University of Exeter. Matthew Johnson said: “This study proves that type 1 diabetes can begin in the first few months of life and even before birth in a small subset of infants.

“We also found that diabetes-detecting young insulin producers were associated with rapid progression to complete destruction of beta cells.”

It is believed for the first time that autoimmune status has not been observed due to a single genetic change in puberty so high in children. The researchers also found that children with such very early onset type 1 diabetes had lower than average birth weight.

Insulin production usually begins before birth and helps the fetus to grow, so the finding suggests that the unborn babies may have already developed.

Dr. of Exeter Richard Oram also said: “The next phase of this work, where we study the immune system in more detail, hopes that it will help explain how it is possible for type 1 diabetes to develop so quickly and Can these insights open up. New ways to prevent or treat the condition in the future. ”

The research also included experts from King’s College London in Seattle and the Pacific Northwest Research Institute of America. It was co-funded by the charity UK Diabetes.

Dr. Elizabeth Robertson, its director of research, said: “These important findings rewrite our understanding of when the condition can shock and when the immune system can begin to go wrong. We need to know now that type 1 diabetes How and why one can develop. At such a young age.

“This can unlock important insights into the causes of type 1 diabetes, typically in people of all ages, and will be necessary to develop treatments that prevent or prevent this life-threatening condition in infants. ”

The findings were published today in the journal Diabetologia.