(NEW YORK) – Depression is the leading cause of disability, with 350 million people affected worldwide.
Although antidepressants have been used for a long time, their effectiveness has been debated.  In a new study published in The Lancet, researchers who tried to solve the problem found that the 21 antidepressants they observed work better than placebo.
The researchers conducted a meta-analysis in which they thoroughly reviewed previous studies.
Among the 28,552 studies analyzed, only 522 were sufficiently rigorous to be included, that is, a total of 116,477 participants treated with 21 different antidepressants.
In addition to finding that all the antidepressants included were more effective than placebo, they compared antidepressants to see if some work better than others, and if people can tolerate the side effects of some more than others.
They noted that some medications, such as Remer on (mirtazapine) and Lexapro (escitalopram), appear to be more effective and tolerable for the average patient.
However, the researchers caution that what works well for one patient does not always work well for another, and that antidepressants take a few weeks to start working on most patients.
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