Coronavirus Vaccine: Two doses of the Oxford / AstraZeneca vaccine provoked good immune response. world News

London: Oxford University’s Kovid-19 vaccine candidate has a better immune response when two full-dose regimes are used instead of a full-dose one-half-dose booster, the university said on Thursday. Cites data.
Developers of the vaccine candidate, which has been licensed to pharmaceutical company AstraZeneca, have already published the results of a later phase trial when half the dose is after one full dose compared to the two full-dose regimes. However, more work needs to be done to confirm that result.
The latest descriptions of Phase I and 2 clinical trials released on Thursday made no reference to the half-dose / full-dose regime, which Oxford has said was “unplanned” but approved by regulators.
Once seen as a frontrunner in the development of the coronovirus vaccine, the British team has been overtaken by American drugmaker Pfizer, whose shots have been launched in the UK and the United States this month.
Data published prior to subsequent Phase 3 trials showed that efficacy was 62% for the test participants given two full doses, but more robust 90% for the small subset given in the first half, then the full. Dosage.
The university said in its statement on Thursday that it had detected a two-dose regime in early-stage trials, a full-dose / full-dose regime and a full-dose / half-dose regime, a potential “dose sparing” “Investigated as strategy.
“Vaccine booster doses have been shown to induce stronger antibody responses than a single dose, the standard dose / standard dose producing the best response,” the university said in a statement.
This vaccine “stimulates broad antibodies and T cell functions”.


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