The finding points the way to a new clbad of antidepressants that could be more free of side effects and more rapid action.
Reference photo, Pixabay.
A team of researchers has linked the depression with low levels in the blood of acetylcarnitine synthesized naturally in the body and also marketed as a nutritional supplement ]according to a study published Monday in the journal Pnas.
The finding, which is based on extensive research with animals, points the way to a new clbad of antidepressants that could be ] more free of side effects and faster action than those currently used, according to one of the lead authors, Natalie Rasgon .  1]
Depression, also called major depressive disorder or clinical depression, is the most prevalent mood disorder in the United States and the world, affecting between 8 and 10 percent of the general population at any given time.  Recommended file: Depression, serious illness and poorly understood
"It is the main reason for absenteeism at work and one of the main causes of suicide . Worse still, pharmacological treatments Current are effective only for about 50 percent of people who are prescribed "Rasgon lamented.
In experiments with rodents, acetylcarnitine deficiency was badociated with a behavior similar to depression while oral or intravenous administration of this substance reversed the symptoms of animals and restored normal behavior.
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The animals responded to acetylcarnitine supplementation in a few days. On the contrary, the current antidepressants took two to four weeks to appear both in experiments with mice and between patients.
"Acetylcarnitine is a crucial mediator of fat metabolism and the production of energy throughout the body and plays a special role in the brain, "explained another author, Carla Nasca Rockefeller University of New York, USA
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In a parallel badysis of the same team, Nasca and colleagues studied men and women aged 20 to 70 who had been diagnosed with depression .
When comparing their blood samples with those of 45 healthy demographically matched individuals, it was found that acetylcarnitine levels in the patients' blood were substantially lower ", according to the authors .
A more detailed report showed that the lowest levels were among the participants whose symptoms were more severe whose medical records indicated that ] were resistant to previous treatments or whose onset of the disorder occurred early in life .
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Levels of acetylcarnitine ] were also lower among patients who reported a history of abuse, neglect, poverty or exposure to violence in childhood .