Challenging a central principle of chemistry

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Steve Granik, director of the IBS Center for Soft and Living Matter and Drs. Huan Wang, Senior Research Fellow, reports with 5 interdisciplinary colleagues in the July 31 issue of the journal Science Common chemical reactions accelerate Brownian diffusion by sending long-distance waves into the surrounding solvent.

The findings violate a central dogma of chemistry, that molecular diffusion and chemical reactions are unrelated. To see that molecules are activated by a chemical reaction is “new and unknown,” Granik said. “When one substance changes by breaking and forming another, it actually moves the molecules more quickly. It seems as if chemical stirring spreads naturally.”

“Currently, nature does an excellent job of producing molecular machines, but scientists in the natural world have not understood well how to design this property.” “Beyond the curiosity of understanding the world, we hope that in practice it can be useful in thinking about the transfer of chemical energy to molecular motion in fluids, to nanorobotics, precision medicine and greener material synthesis. “

Unexpected waves generated by chemical reactions, especially when catalyzed (not consumed by the substances themselves), propagate long distances. For chemists and physicists, this work challenges the textbook’s view that molecular motion and the chemical reaction are decomposed, and that the reaction only affects the nearby vicinity. For engineers, this work demonstrates a powerful new approach to designing nanometers at a truly molecular level.

Screening 15 organic chemical reactions, researchers have studied chemical reactions operating with wide application within the organic chemical, pharmaceutical and materials industries. For example, the clicks’ reactions aid the assembly of libraries of biomedical compounds for screening and the Grubbs reaction is used for plastic fabrication. Their economic impact is major. Estimates suggest that the majority of all products manufactured require catalysis at some point in their production order.

Wang commented enthusiastically “Now, we are like a child taking its first steps and have a very exciting opportunity to grow this child.”

In designing their study, researchers bio-inspired seeing that the motion could be driven by enzymes and other molecular motors that are prevalent in living systems. In this same research center, Dr. Shown work previously done by Ah-Young Ji. But these reports can be extended correctly outside of biology, but there was no consensus among scientists. Analyzing the problem, the researchers argued a high-risk, high-payoff. He hypothesized that the phenomenon would create an approach to understanding molecular machines in the real world.

Testing their hypothesis, the team developed new analytical techniques. Professor Tsavi Tallasty, a professor, predicted that the catalyst in the reaction gradient should go ‘upward’ towards low propagation. To test the idea, a microfluidics expert, Professor Yu-kyong Cho, created a tailor made microfluidics chip. Dr. Ruoyu Dong, a research fellow, performed numerical computer simulations. “Our interdisciplinary team responded incredibly fast to research opportunities, thanks to the research independence of the Korean Institute for Basic Science,” Granik said.

The team presents guidelines showing that the amount of diffusion growth in different systems depends on the energy release rate. These guidelines can be practically useful as they can predict effects in as-yet-unacted responses. In addition, the study is very useful to expand the understanding of active materials, a collective term that traditionally refers to things such as cells and microorganisms.

Granik concluded: “The field of active materials, quite new and rapidly expanding, is enriched by the discovery that chemical reactions behave as nanosimers made of individual molecules that excite reaction soups. Of active materials. The concept has shown its value in challenging. The central dogma of chemistry. “

These findings were published in the July 31, 2020 issue Science magazine. The study was carried out at the IBS Center for Soft and Living Matter by authors Huan Wang, Myeogon Park, Ruoyu Dong, Xuanyong Kim, Yun-Kyung Cho, Tsavi Talsti and Steve Granik.

Spinning chemicals for rapid reactions

more information:
Promotes molecular dynamics during common chemical reactions. Science (2020).… 1126 / science.aba8425

Provided by Institute of Basic Sciences

Quotes: Retrieved 30 July 2020 from, challenging a central theory of chemistry (2020, 30 July).

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