Can Israeli Mutation Turn into Israeli Mass Vaccination Campaign?


Israel’s mass vaccination campaign running parallel to an active coronavirus outbreak could create “evolutionary pressure” on the virus, resulting in an Israeli version that could be resistant to the vaccine or have some advantages.

So in a paragraph of a nine-page report on mutations, the Coronavirus National Information and Knowledge Center was opposed on Saturday night.

The result was a frenzy of headlines and terror.

Already, the world learned over the weekend that the British version, which has spread like wildfire across Israel, may be more deadly than originally thought.

In addition, government and health officials have feared that variants entering Israel through Ben-Gurion Airport may go against the country’s vaccination program and the crisis may hurt its capacity. This includes the South African version, which was brought to Israel via South Africa and Dubai, and preliminary studies have shown some vaccines to be less effective.

To date, however, “there are no known meaningful Israeli mutations,” head of public health services Prof. Sharon Alloy-Preuss told Cannes News on Sunday morning.

But he said that “mutations can develop wherever there is a virus.”

“Viruses acquire persistent variants,” said Prof Efrat Levi-Lahad, director of the Institute of Medical Genetics at Shera Zedek Medical Center. he said Jerusalem Post These changes occur when the genome changes in some way during replication.

“Imagine if you were to make handwritten copies of the genome – there is a very high probability of typographic error,” explained Jonathan Gershony, professor at the Shumanis School of Biomedicine and Cancer Research at Tel Aviv University. “So, while printing books or copying documents, typos is common and understandable, the same is true when copying a genome. But we call those typos mutations, and those mutations that affect The virus is a mutant or variant. “

LEVY-LAHAD stated that most of the changes are “silent” and have no effect on virus proteins or anything else. But sometimes these “typos” can have a profound effect, Gershony said. For example, “My wife is tough” vs. “My life is hard” – the two phrases have a different letter, but different meanings.

Mutations stated that mutations could increase the virus’s ability to become infectious, render the virus more pathogenic, or make it less susceptible to neutralizing stimulated or induced antibodies through vaccination. On the other hand, he stated that some mutations may make the virus less efficient and eventually cause petting.

Vaccination could theoretically accelerate the growth of a virus, Levy-Lahad said.

“Until coronovirus, one of the major health issues was that many germs had become resistant to antibiotics because the population was given too much, often unnecessarily, and a way for germs to become resistant to those antibiotics. found it. Those germs that manage to get resistance become more potent because they will prevail, ”she explained.

“If someone is vaccinated, they may still get some level of infection, then there are coincidental variants that may antagonize the antibodies you have for vaccination.”

He said, “Basically, it’s a numbers game. If you have a lot of sick people and a lot of people get vaccinated – and if the vaccination doesn’t completely rule out infection – just because you have a lot of people who can infect coronovirus and a lot of hosts In which it can develop, variants can be created. “

But he said that this does not mean it will happen.

The KNOWLEDGE Center’s report warned that this imaginary “Israeli mutation” virus may have some ability to evade the immune response elicited by vaccination. It can spread rapidly within the population – especially in light of the fact that children are not getting the jab.

But Levi-Lahad said the situation is not so black-and-white – it is “no-or-no incident.”

“It may be, for example, that vaccination does not completely eliminate infection, but it reduces the rate of critical illness by 2% [one in 50] One in 1,000 – that’s still going to have a big impact, “she said.

He stated that the influenza vaccine is an example of a vaccine that has to be updated because the virus mutates.

“I don’t know if anyone showed it as a result of the rate of vaccination,” Levy-Lahad said.

However, she said the fear of mutations is an argument to follow the Ministry of Health regulations and reduce infections.

Furthermore, as Gershony emphasized, while Israel has no control over how random mutations occur, the country does not have control over how to reduce infectious rates.

“Regarding the specificity of Israel or not, one has to remember that among the countries with the most vaccines, we are ranked fifth. The United States is vaccinated with 21 million people, an infectious rate of 77,000 people per million, and well per The day is leading with over 150,000 infections, ”Gershony said.

“The number of infections due to lockdowns in Israel is slowly dropping – and hopefully it will continue to do so,” he said. “It is our responsibility to prevent the escape mutation by increasing the vaccination campaign to ensure the safety of our population.”

Gershony said that with replication, there is a direct relationship between how many copies are being made at a given time, which are going to accumulate. If the rate of infection is low, then the number of mutations decreases relatively. Anytime the rate of infection increases, errors will increase.

What I really worry about when I come out with these declarations, as if an Israeli mutation is going to happen, is that they play into the hands of those who say there is no use in vaccinating them Or it is not really necessary, Levi-Lahad emphasized.

“Vaccination is the best thing we have right now.”

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