In a recent study done in mice, researchers became one step closer to understanding who was actually searching for that exercise. Strengthens brain flexibility to stress. Studies help animals cope with stress by enabling upticks to an important nerve protein, the study suggests. This process affects stress levels, food consumption, cognition and mood.
Taking advantage of this finding, the researchers were also able to genetically alter gaolin’s level of sedentary mice, which reduced their anxious response to stress.
The study’s authors point out that this study helps to reduce the biological mechanisms that positively impact exercise. Although further human experiments are needed to confirm these findings, researchers offer practical advice for those seeking to achieve these benefits: Do regular, aerobic exercise.
“Absolutely not, and then suddenly going for a 10-mile run before a stressful event, which is not as useful in jogging regularly for 3 miles over several months,” researchers David Wenshenker And Rachel Tillage, tell me In the shlokas by email.
This is because, based on these results, a history of exercise affecting the immediate physiological response (such as the release of cortisol) during a stressful event does not affect, Weinshenker and Tillage explain. Instead, exercise increases flexibility in behavior after exposure to stress.
“This may suggest that increased exercise does not affect our immediate feelings of stress, but allows us to cope with stress in a healthy way,” the co-author says.
These findings were released on Monday Journal of Neuroscience.
Brain System Discovery – Research shows that exercise protects against the deadly effects of stress in both mice and humans. Galanin, the important brain protein that regulates stress and mood, is expressed in similar areas of the brain of both animals.
To study how these factors affect each other and affect each other, the study team turned to mice.
“Because of moral and technical limitations, mechanical questions are difficult to answer in humans, so we used mice,” says Weinshanker and Tillage. With these overlapping properties, the team adds that physical activity-related stress may be the neurobiological substrate species underlying the role of galanin in resilience.
“One major implication from this study is that the galanin system may be A possible goal For future treatments … “
Stressful event – aka worrying behavior of mice 24 hours after a stressful event. They also analyzed their levels of galanin and investigated its source.
Half the mice had regular access to an exercise wheel in their cage, while the others had no running wheel. The rats steadily increased their running distance in the first week, after which they ran at a speed of about 10–16 km per day. The researchers tracked the mice’s activity for three weeks.
The exercisers showed less anxious behavior after the stressful event compared to the mice who did not exercise. Exercise mice also had Elevated galanin level In locus coerulus, a group of neurons involved in the brain response are involved in the stress response.
Mice spending time in the third week correlated with the amount of galanin in the locus coerulus, which in turn correlated with their degree of stress resilience.
Based on these findings, the team increased gallons in locus coerulus in genetically sedentary mice. This gave these passive rats the beneficial stress flexibility effects of exercise, without altering their physical activity patterns.
If further human experiments confirm these findings, it may mean Hijacking the galanin system Can help people get the stress flexibility benefits of exercise, even if they are not able to work outdoors.
“These findings differentiate a specific biological mechanism we know of, which increases galanin in the local coerulus – whereby exercise can affect how we respond to stress,” Wensenecker and Tillage explain. “One of the major effects of this study is that for those who are not able to exercise, the galanin system may be a potential target for future treatments to achieve positive effects of exercise on stress resilience. . ”
Interestingly, the increased gallon did not affect other aspects of the mice’s behavior, suggesting that only gallanin could be recruited during periods of high stress, the team says.
More human data is needed to find out how or how much exercise affects this stress-resilience effect. But based on current evidence, researchers say they can provide some general guidance:
- Aerobic exercise (such as walking, running, biking, swimming) probably has a greater effect on stress flexibility than non-aerobic exercise (such as lifting weights).
- Exercise needs to be regularized; Completed a few times a week. HIIT workouts are unlikely to be helpful in regular hiking or elliptical hitting just before a crimping or prolonged stressful event.
abstract: The neuropeptide galanin has been implicated in stress-related neuropacitric disorders in humans and rodent models. While pharmacological treatments for these disorders are ineffective for many individuals, physical activity is beneficial for symptoms related to stress. Galanin is highly expressed in the noradrenergic system, specifically the locus coerulus (LC), which is deformed in stress-related disorders and activated by exercise. Galanin expression is elevated in LC by GC exercise, and blockade of galanin transmission increases exercise-induced stress resistance. However, most research on this topic has been done in mice, so it is unclear whether the relationship between exercise and gallons is specific to the species. In addition, prior studies have involved the use of intracbroventricular galanin receptor antagonists specifically to define a causal role for LC-derived galanins. Therefore, the goals of this study were twofold. First, we investigated whether physical activity (chronic wheel running) increases stress flexibility and galanin expression in the control line of male and female mice. Next, we used transgenic mice, which overexpress galanin in noradrenic neurons (Gal OX), to determine how chronically elevated noradrenic-derived galanin, alone, elicits anagenic-like responses to stress. Changes. We found that three weeks Without preparation Access to a running wheel in their home cage increased galanin mRNA in the control line of mice, which was correlated and provided flexibility for stress. The effect of exercise was phenocopied by galanin overexpression in noradenergic neurons, and Gal OX mice were resistant to the angiogenic effect of optogenetic LC activation. These findings support a role for chronological increase in mediation to overcome stress.