Botox injections can reduce depression

Physicians inject Botox to smooth facial wrinkles and cause health problems such as severe sweating, uncontrollable eyelid nap, chronic migraines, hyperactive bladder and neurological disorders that cause muscle contractions and pain in the neck and shoulders.

Botox is a toxin produced by the bacterium Clostridium botulinum, which works by weakening or crippling specific muscles or blocking certain nerves.
Over 264 million people worldwide suffer from depression. According to the study published on Thursday in the journal Scientific Reports, common treatments for depression are not effective for about one-third of these treatments, even when they stick to their treatment plans and tolerate medications .
This deficiency has prompted doctors to explore alternative treatments, such as psilocybin (the active ingredient in psychedelic mushrooms) doses, ketamine infusions and, more recently, Botox injections. Prior studies of the past 15 years have found that the drug may have an antidepressant effect.

How and for how long, treatment may work for depression is unclear, but researchers have thought that Botox can disrupt a feedback loop between negative facial expressions in the globular region – behind the skin between the eyebrows And above the nose, where “” sore muscles “- and negative emotions.” Because of this hypothesis, those studies mainly used forehead injection to treat depression, but were limited in terms of sample size, unstable functioning, injection sites, and mixed results.

Botox for various conditions

To address the limitations of earlier studies, researchers analyzed more than 45,000 reports of adverse events resulting from botox treatment from the US Food and Drug Administration’s adverse event reporting system. The system supports FDA monitoring of adverse effects of medications reported by patients, health care professionals, and pharmaceutical manufacturers to FDA through MedWatch, FDA’s Safety Information and Adverse Event Reporting Program.
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They divided patients into eight groups related to medical symptoms, often treated with Botox. these were:

  • Cosmetic is used for wrinkles, facial bumps, dermal filler or more
  • Migraine
  • Limb spasms (when muscles tighten or tighten and stop movement, speech and walking)
  • Neck pain
  • Involuntary blink or spasm of their eyelids
  • excessive sweating
  • Extreme destruction
  • Neurological and bladder disorders

Each group was divided into two groups, with one group receiving Botox for its conditions and the other not. Patients receiving botox injections to treat excessive sweating, facial wrinkles, migraines, cramps, and cramps reported 40% to 88% lower levels of depression than those who received different conditions for the same condition. – Different treatment.

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“We found that (the effect) does not depend on the location of the injection and that it (does not depend on the medical conditions), which are quite diverse for Botox,” said Ruben Abogn, lead author of the study and California of San Diego A professor at the Scaggs School of Pharmacy and Pharmaceutical Sciences at the university.

“Its implications are attractive because it means that depression can be cured by means (means) and that injections into the facial muscles may not necessarily be undesirable in some cases,” said Abgan.

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Although the facial feedback loop hypothesis is a “plausible and robust mechanism”, the study said, the findings may suggest that there are other, more complex ways through which Botox may have an antidepressant effect.

Botox can be transported to central nervous system structures that are involved in regulating our moods and emotions. A 2019 study found that Botox injections for muscle spasms can go beyond the injection site and affect opposing muscle groups and reflexes through altered neural activity.

“A fraction of that gets into the systemic distribution through the bloodstream … and then somehow it reaches into the brain and probably affects different places” that may be associated with depression, Abyan said.

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The interaction between muscles and mood is not limited to the facial response process.

Muscle tension in various areas of the body is a common symptom of depression and can be a physical manifestation of the disorder and a booster of depressed mood. This is why progressive muscle relaxation, which mentally exhausts a person and then relaxes their muscles, is an established treatment in the psychiatric field.
Depression is associated with increased muscle tone, which describes the maintenance of partial contraction of muscles. A decrease in muscle tone as a result of Botox injections, which weakens the muscles, can combat depression.

“Imagine when you get depressed, not only a spot on your forehead – that creates this wrinkled wrinkle – but all the muscles get tense and constricted,” Abyan said. “Then there is a distributed muscle memory. Basically by breaking all of that memory down by resting them, you break the reaction between the head and the muscle in this case.”

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Since some of these conditions are chronic and cumbersome, they can cause secondary psychiatric problems such as depression. If Botox overcame these problems, it can relieve depression.

“This study makes me wonder if we can also have a physical feeling of depression if we have muscle cramps or sweating, and by treating this ‘feeling of depression’ we can not only treat a patient’s medical problem (but) Can affect, but also their psychological health., “Dr. Jason Reichenberg, a dermatologist medical group dermatologist and an associate professor of internal medicine at the University of Texas at Austin, said in an email. Reichenberg was not involved in the study.

Botox’s future

According to the study, the FDA reporting system is voluntary and open to the public, negative reactions to Botox may be low and biased. Demographics, treatment dose and duration, medical records and other details about other drugs or supplements were also limited.

Studies of past data “may not establish a cause-and-effect relationship, but they help us focus our future research,” Reichenberg said. “The results are even more impressive when you find out that the authors removed any patients who were taking antidepressants so as not to be biased; if they kept that other data, their results would be even stronger. Were.”

Researchers suggested that Botox injections may be an alternative treatment for those who have had no luck with general treatment for depression, and also for those who are experiencing both chronic conditions and depression.

“If one needs to be treated for excessive saliva, cramps or bowed heads and they are depressed at the same time, the finding suggests that (Botox) may be beneficial for both indications,” Abigyan said. “If you can kill two birds with one stone, I think that is definitely something to consider.”

Abagan said depression carries with it risks such as suicide risk, but injects Botox, what patients can handle if the dose is unsafe. Additional studies on Botox treatment for depression need to understand the possible side effects and ensure a safe path to mental well-being.


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