New York: Bacteria present in the mouth that lead to gum disease may also increase the risk of esophageal cancer, according to a study.
Oesophageal cancer is the eighth most common cancer and the sixth cause of Oesophageal cancer is a highly deadly cancer disease, and there is an urgent need for new prevention pathways, risk stratification and early detection, "said Jiyoung Ahn, an badociate professor at the University of New York in the United States.
Previous research has shown that periodontal disease caused by certain oral diseases The microbiota has been badociated with several types of cancer, including oral and head cancers and neck.
This study examined whether oral microbiota was badociated with a subsequent risk of esophageal adenocarcinoma (EAC) or esophagus, eal squamous cell carcinoma (ESCC).
Researchers collected oral wash samples from 122,000 participants in two large health studies.
In 10 years of follow-up, 106 participants developed esophageal cancer.
In one In a prospective case-control study, the researchers extracted DNA and sequenced oral wash samples, allowing researchers to compare the oral microbiomes of esophageal cancer cases and cancer-free cases.
Certain types of bacteria were badociated with an increased risk of esophageal cancer. For example, higher levels of the bacterium Tannerella forsythia were badociated with a 21 percent higher risk of CAD.
The bacterium Porphyromonas gingivalis was badociated with an increased risk of ESCC. Both species of bacteria are related to gum disease, Ahn said.
The study, published in the journal Cancer Research, showed that some types of oral bacteria were badociated with a lower risk of esophageal cancer. For example, the Neisseria bacteria was badociated with a lower risk of CAD.
The finding in Neisseria indicates that certain bacteria may have a protective effect, and future research could examine whether these bacteria could play a role in the prevention of esophageal cancer. 19659002] "Our study indicates that learning more about the role of oral microbiota can potentially lead to strategies to prevent esophageal cancer, or at least identify it at earlier stages," Ahn said.
"The next step is to verify if these bacteria could be used as predictive biomarkers," he said.
The study confirms that good oral health, including regular tooth brushing and dental visits, is an important way to protect against periodontal disease and the growing list of health conditions badociated with this, the researchers said.