Liverpool are expected to run out of Jordan Henderson and Naby Keita when they face Belgrade's Red Star on Tuesday.
The midfield duo has been out of action since mid-October because of problems in the hamstring and manager Jurgen Klopp is willing not to rush the pair.
Club captain Henderson has not appeared since he retired at halftime against Huddersfield on October 20, losing wins over Red Star and Cardiff, as well as yesterday's draw with Arsenal.
Speaking ahead of the 1-1 against the Gunners, Klopp said: "Hendo feels very good, but it will probably be the start of the week when he returns to training.
"Naby [will be the] End of this week. There is not a big difference in terms of pairing, but that's what it looks like. "
Klopp's comments suggest he does not expect the duo to be available for the trip to Serbia and that, instead, he hopes they can face Fulham next weekend.
"In football, a not too serious injury still takes two, three or four weeks," he said.
"You're lucky if you only have one injury like that, but that only means in the Premier League [you will miss] 20 games!
"They are completely on time, if you want. It is as we expected.
"We did not have to rush, we really could not, but there was no reason to try.
"If the next game would be next Friday, then probably both would be in shape, but the next game will be on Saturday and the other on Tuesday, so it could be a bit tight."
Given that Henderson and Keita will likely be discarded, Georginio Wijnaldum, Fabinho and James Milner are more likely to continue in midfield three.
Xherdan Shaqiri started wide during the 4-0 victory over Red Star at Anfield, as Klopp only deployed two central midfielders, but the Liverpool boss may be more conservative away from home.
Meanwhile, Dejan Lovren hopes to win a center retreat, although Joe Gomez impressed once again with Virgil van Dijk in the Emirates.
Trent Alexander-Arnold could be the man to lose if Lovren returns, although the 20-year-old offers a more offensive option than Gomez on the right-back.
The Reds are currently at the top of their Champions League group, but they sit a point behind Napoli and two of the Paris Saint-Germain clearings with three remaining matches.
Liverpool predicted lineup against red star Belgrade
(4-3-3) Alisson; Alexander-Arnold, Gómez, Van Dijk, Robertson; Fabinho, Wijnaldum, Milner; Salah, Mane, Firmino