AstraZeneca vaccine trial begins investigation

A source familiar with the incident, who spoke on condition of anonymity, said in an interview on Tuesday that the suffering volunteer had experienced a condition called transverse myelitis or symptoms consistent with spinal inflammation.

In a statement to reporters on Wednesday, AstraZeneca’s spokesman, Michel Meisel, said the person did not have a confirmed case of transverse myelitis. He said the company’s chief executive, Pascal Soriott, said in a phone call reported by STAT that there is no final diagnosis and there will not be one until further tests are conducted. Those tests will be routed to an independent safety committee that will review the incident and establish a final diagnosis. “

The company did not respond to a request for clarification on whether transverse myelitis was suspected.

According to the National Institutes of Health, transverse myelitis is relatively rare among approximately 1,400 people in the United States each year. The condition may cause pain, muscle weakness, paralysis or bladder problems. The root cause is often mysterious, although doctors believe that the syndrome usually results when inflammatory reactions in the body flare up, sometimes as a response to ongoing or past infection, University of California, Dr., a neurologist in San Francisco. Felicia Chow said. . “It’s not uncommon that we never find out the cause,” she said.

He said there is some past speculation that vaccines may be capable of triggering transverse myelitis. A handful of vaccines have previously been bound in a gamut of other autoimmune disorders, including Guillain-Barre syndrome, in which the immune system attacks the nerves. However, such complications are rare.

Both transverse myelitis and Guillain-Barré syndrome have been indicated as potential complications of Kovid-19.

Although vaccines are designed to be harmless to humans, they must reduce the body’s defenses to marshal a protective immune response. But if the wrong subset of cells or molecules is transformed into action, or if the body cannot rein in its reactions, it can set off a cascade that begins to damage healthy tissues, Drs. Said Serena Spudich, a neurologist at Young University.