Published: December 6, 2017 21:04
The implantation of artificial ovaries can be a safer, natural and effective alternative in menopausal women who face hot flushes, sleeping problems, weight gain and bone deterioration due to the loss of ovarian function, According to a study of mice has suggested.
Women who experience menopause lose their ability to produce hormones such as estrogen and progesterone and, as a result, face these symptoms. While hormone replacement medications help in the production of these important hormones, they are not recommended for long-term use because of the increased risk of heart disease and breast cancer.
The findings showed that laboratory-modified ovarian transplantation may be a better alternative for menopausal women than regular ingestion of synthetic hormones.
"The treatment is designed to secrete hormones naturally according to the needs of the body, rather than the patient taking a specific dose of medication every day," said Emmanuel C Opara, professor at Wake Forest Baptist Medical Center in North Carolina, USA UU
"The safe replacement of hormones will probably become increasingly important as the population of older women grows," Opara said.
To design the bioartificial ovary, as reported in the journal Nature Communications, the team isolated the two types of cells, the theca and granulosa, found in the ovaries, of rats.
A thin membrane was used as ac apsule to contain the cells and then implanted in rats to which the ovaries were removed.
The new treatment could produce estrogen and progesterone hormones naturally and have better bone and uterine health, as well as prevent the symptoms of menopause such as bone deterioration, weight gain and sleep problems.
"This study highlights the potential utility of cell-based hormone therapy for the treatment of conditions associated with loss of ovarian function," Opara said.
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