- Note that this observational examine discovered an affiliation between increased reported antioxidant consumption and diabetes incidence in ladies.
- Be conscious that outcomes of research based mostly on food-frequency questionnaires have not often been validated in randomized trials.
A weight-reduction plan excessive in antioxidants might badist defend in opposition to diabetes, a brand new examine discovered.
Among middle-aged ladies, these in increased quintiles for whole antioxidant capability reported an related decrease danger for the event of kind 2 diabetes versus ladies within the lowest quintile (P<Zero.0001 for all), in response to Francesca Romana Mancini, PhD, of the French National Institute of Health and Medical Research in Paris, and colleagues.
However, this risk-reduction affiliation plateaued when whole antioxidant capability reached 15 mmol per day, the researchers reported within the examine, on-line in Diabetologia.
“We know that diet plays a major role in the prevention of type 2 diabetes, but we are constantly looking for innovative ways to characterize someone’s diet that could help him or her adopt healthier food choices,” the senior examine writer, Guy Fagherazzi, PhD, informed MedPage Today. “Studying the whole antioxidant capability of the weight-reduction plan presents this risk.
“It is quite well established in the literature that some foods rich in antioxidants — coffee, vegetables, foods rich in vitamin C or E, etc. — are badociated with a lower risk of developing type 2 diabetes, but these studies looked only at isolated nutrients or food groups, not at the total antioxidant capacity of the diet.”
The staff collected information on 64,223 older ladies (imply age of 52 ± 7 years) with dietary info who had been included within the E3N-EPIC cohort, which was geared toward badessing danger elements for most cancers and different persistent ailments similar to diabetes. Exclusion standards included pre-existing heart problems, pre-existing diabetes, and potential pre-existing however not identified diabetes, in addition to pre-existing most cancers.
During a 15-year follow-up, 1,751 ladies had been identified with kind 2 diabetes, recognized through self-reporting and insurance coverage drug reimbursement info. Dietary information was collected through a 208-item self-report questionnaire. An estimated antioxidant capability of meals was recognized with the ferric ion-reducing antioxidant energy methodology, which was based mostly upon the single-electron switch methodology. However, espresso was excluded from the whole antioxidant capability from weight-reduction plan, as a result of, because the authors wrote, “there is no consensus on whether the antioxidants present in coffee are actually absorbed, and because coffee has such a high antioxidant content that it would drive the badociation with type 2 diabetes.”
The researchers adjusted the multivariable evaluation for a lot of elements, together with smoking standing, bodily exercise, schooling stage, hypertension, hypercholesterolemia, familial diabetes historical past, power consumption, alcohol consumption, wholesome dietary adherence, and BMI.
In a sensitivity evaluation together with antioxidants from espresso, the affiliation with kind 2 diabetes prevention was nonetheless obvious, though barely weakened amongst those that consumed lower than 247 mL per day of espresso (P=Zero.003):
- 11.30-13.93 mmol/day (Q3): HR Zero.70 (95% CI Zero.57-Zero.85)
- 13.94-17.55 (This autumn): Zero.62 (Zero.50-Zero.77)
- >17.55 (Q5): Zero.61 (Zero.48-Zero.78)
The relationship was not statistically important amongst those that consumed over 247 mL per day of espresso.
Fagherazzi stated that he and his group weren’t stunned by the findings: “We were expecting to observe a decreased risk of diabetes in people with a diet rich in antioxidants. Moreover, we have shown that this decreased risk was observed independently of various type 2 diabetes risk factors, including the total daily energy intake and body mbad index. However, what we did not really expect was the plateau of risk observed above 15 mmol/day, as if the organism’s capacity to absorb antioxidants from the diet was saturated.”
He added that his group plans to proceed researching this matter with follow-up research. “The initial objective of this work was to provide new evidence in terms of primary type 2 diabetes prevention. Now we will focus on tertiary prevention: we will now evaluate if a diet rich in antioxidants is badociated with a lower risk of diabetes-related complications (cardiovascular diseases, retinopathy, nephropathy) in our E3N-AfterDiab study composed of 3,500 women living with type 2 diabetes.”
The examine was supported by a grant from the World Cancer Research Fund and by a grant for the E4N examine from the Agence Nationale de Recherche. The validation of ladies with potential diabetes was supported by the European Union InterAct undertaking.
None of the authors reported any related disclosures.
F. Perry Wilson, MD, MSCE Assistant Professor, Section of Nephrology, Yale School of Medicine and Dorothy Caputo, MA, BSN, RN, Nurse Planner