Antibodies that can neutralize coronaviruses found by the University of Pittsburgh


An antibody that may be effective in neutralizing coronaviruses has been found by researchers at the University of Pittsburgh School of Medicine (UPMC).

The antibody, which is 10 times smaller than a full-size antibody, has been used to make a drug called A8 that researchers hope may be able to prevent and treat the virus.

The researchers reported that the drug has so far proven to be “highly effective in preventing and treating SARS-CoV-2 infection” in mice and hamsters.

Researchers said the drug also indicated that it would not have negative effects in people, as it is not linked to human cells.

“Ab8 not only has potential as a therapy for Kovid-19, but can also be used to protect people from SARS-CoV-2 infection,” Pitt and co-author of the Division of Infectious Diseases at UPMC John Mailers said. . Pitt’s Jianglei Liu is also the study’s co-lead author.

“Large-sized antibodies have worked against and tolerate other infectious diseases, we hope that this can be an effective treatment for patients with Kovid-19 and for the protection of those who have There has never been an infection and is not immune, ”Dr. The mailers added.

Specifically, the researchers said they were “thinking outside the box” about how the drug could be administered. The report suggested that alternative routes for administration may be possible, including inhalation or a pointed plaster-like patch.

The report states, “Its small size may give it as an inhaled drug or intradermally via an IV drip, rather like most monoclonal antibodies currently in development.”

During the initial trials, even at the lowest dose, the A8 infectious virus content decreased 10-fold in those mice that were untreated, compared to mice that were untreated.

“The Kovid-19 epidemic is a global challenge facing humanity, but it is likely to overcome biomedical science and human ingenuity,” Dr. Also called Mellors, Distinguished Professor of Medicine, who holds the Andy Chair for Global Eradication of HIV and AIDS at UPMC. .

“We hope that the antibodies we have discovered will contribute to that victory.”