Antibiotic use in infants associated with allergies, asthma and other conditions, study finds

According to the study published on Monday at the Mayo Clinic, infants and children who receive a single dose of antibiotics include asthma, eczema, hay fever, food allergies, celiac disease, weight and obesity problems, and later attention in childhood Hyperactivity disorder caused by deficiency was more likely. Action.

Many antibiotic treatments under the age of two years were associated with a child with multiple conditions, the study found that diseases caused by the child’s gender, age, type of medication, dosage and number of doses varied.

“We would like to emphasize that this study is one of these conditions, not a work-cause, association,” said senior study author Nathan Lebersseur, a researcher at the Mayo Clinic Center on Aging . “These findings provide an opportunity to target future research to determine more reliable and safe times, doses, and types of antibiotics for children in this age group.”

The researchers analyzed data from more than 14,500 children who are part of the Rochester Epidemiology Project, a long-term study that analyzes the medical records of volunteers in Minnesota and Wisconsin. Some 70% of the children in the study received at least one antibiotic, with the majority receiving antibiotics.
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“Among children who received one or two prescriptions, only girls were at significantly higher risk of developing asthma and celiac disease than those who did not,” LeBrasseur and his team wrote. “Conversely, receiving three to four prescriptions was associated with a higher incidence of asthma, atopic dermatitis and overweight in both sexes, ADHD and celiac disease in girls, and obesity in boys.”

The study found that infants of both sexes who received five or more prescriptions “had a significantly higher risk for developing asthma, allergic rhinitis, overweight, obesity, and ADHD.” Girls were at higher risk of celiac disease.

The study found that penicillin, one of the most commonly prescribed antibiotics, “was associated with greater risk for asthma and overweight in sex and ADHD in girls and obesity in boys, while they were more prone to autism in girls”. Were associated with lower risks. “

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The study found that another commonly prescribed antibiotic, cephalosporin, was associated with a higher risk for most conditions and, “specific, autism and food allergies”.

A microbiome connection?

Why would antibiotics have such an effect – if indeed future studies replicate the connection?

This is likely due to the disintegration of bacteria in a child’s intestine, which is essential for proper development of the immune system, nerve development, body composition and metabolism, LeBrasseur and his team said.

Antibiotics do not discriminate between “good” and “bad” bacteria in the digestive system, killing them all and leaving the intestine untouched. Appropriate microbiome distribution. We need some bacteria to absorb nutrients, break down food in the intestines and protect the entire digestive system from pathogens.

An explosion of research about our microbiome has found that it can play a role in everything from how we respond to chemotherapy to our brain chemistry and immune response.

The study noted, “When antibiotics were first developed and deployed, the overarching idea was control of pathogens. We now realize that their widespread application has considerable collateral effect on the microbiome, particularly in developing children. Can be of importance, ”the study said.

Author of “Baby and Child Health” and the American Academy of Pediatrics, pediatrician Drs. “The use of antibiotics may be the least helpful in preventing antibiotic resistance, but may have a role in the preservation of microbiomes based on this study,” said Jennifer Shue. “Heading Home with Your Newborn.” Shu was not involved in the study.

“Of course, further studies will need to corroborate or refute these findings,” she said, because it is unclear whether the study’s findings are “correlative or causal.”


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