After two days by the Los Angeles Public Health Department, the much-discussed UK variant of the Kovid-19, known as B.1.1.7, was identified in the region, with the California Department of Public Health revealing that another Less-known tension was also seeping into the county.
Known as the L452R, the newly-announced arrival was first identified in Denmark in March of last year. It showed in early May 2020 in California.
According to the California Department of Public Health, Santa Clara County has indexed a large number of positive samples collected from community testing sites and outbreaks in the county. L452R was present in samples from the community and in several large outbreaks, including outbreaks where a large number of people contracted the virus.
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Santa Clara County Health Officer Drs. “This type was identified in several major outbreaks in our county,” said Sarah Cody. She called that correlation “a red flag and should be investigated further.”
A variologist and professor of laboratory medicine at UCSF, Drs. Charles Chiu, who genetically sequenced test samples to identify new variants, said the L452R increased from about 3.8% of the tested samples to more than 25.2% at the end of November to December 2020, beginning in January 2021. In late December.
The L452R variant affects the virus’s spike protein, so there is a chance that currently developed vaccines will be less effective against it. The vaccines, now administered in the United States, were designed to provide immunity to people by inhibiting the spike proteins of the virus.
An article from Cell.com states that L452R “has decreased sensitivity to neutralize mAbs (monoclonal antibodies),” which is currently used in approved vaccines to disrupt connections between viruses and spike proteins of infected cells Is used for.
Chiu stated that early studies of L452R spike protein mutations suggest that it is less susceptible to neutralizing antibodies in vaccines.
The new version has also been found in Los Angeles, Mono, Monterey, Orange, Riverside, San Francisco, San Bernardino, San Diego, San Luis Obispo, Humboldt and Lake Counties. Because genomic sequencing is sparse, it is currently unknown how prevalent L452 is statewide, nationally or globally.
“This variant carries three mutations in the spike protein, including L452R, which it uses to bind to and enter virus cells, and is the target of two vaccines that are currently available in the United States,” Dr. Chiu said.
And there may be another issue with one of those vaccines.
State Epidemiologist of California Drs. Erica Paine said Sunday that there were “more than normal” clear reactions to Modern’s batch of vaccines at a San Diego-area clinic.
“Out of an excessive abundance of caution,” Pan recommended that clinics should stop using the dose from that specific batch until it is investigated.
California received approximately 330,000 doses from the lots in question. This is equivalent to about 10% of all vaccines distributed across the state to date.
On Monday, the state’s numbers were mostly reduced, with just over 30,000 new cases, 201 new deaths, 20,968 virus patients hospitalized and 1,113 ICU beds available. This is the lowest number of ICU beds available during the last pandemic, and is therefore worrisome.
UK version on the horizon, B.1.1.7. K is potentially more contagious. Los Angeles Public Health officials over the weekend confirmed the first case in that area.
Although the first detection of stress may appear in Los Angeles County on Saturday, health officials said in recent weeks that it had been circulating in LAB1.1.7 long before. It had earlier made its way through the San Diego and San Bernardino counties. Earlier, the strain was found in Colorado, where it made its US landfall.
The CDC warned that the presence of B.1.1.7 could mark a new phase of “exponential growth” in total Kovid-19 cases.
Barbara Ferrer, director of Los Angeles Public Health, said on Friday, “Current estimates by experts predict that this version may dominate locally by March if left uncontrolled.”
Now we can also add the danger of a potential vaccine-resistant strain, L452R.
As a result, LA County officials are discussing the possibility of new restrictions for shutdown-weary counties.