Nigeria: Minerals of life – Coenzymeq10



COENZYMEQ10, also known as CoQ10 or ubiquinone, is a chemical molecule soluble in fats and similar to the vitamin present in all cells of the body. The Q in the formula represents the chemical group Quinona, while 10 represents the number of isoprenyl subunits attached to it.

CoQ10 is found mainly in the mitochondria of cells where it plays a role in the electron transport chain in cellular aerobic respiration. This is the process of energy generation (ATP) in the mitochondria of cells. It has the ability to exist in completely reduced and totally oxidized states and this property of CoQ10 will be the basis of our discussion regarding its functions in the body.

Between the extremes of the existence of CoQ10 in the body, the completely reduced and completely oxidized are three states. These states are completely oxidized (ubiquinone), intermediate semi-ubiquinone and totally reduced states (ubiquinol).

CoQ10 is an electron transporter and this allows it to function in aerobic cellular respiration for the production of energy. Being a fat-soluble molecule, it easily passes through cell membranes as a component of the electron transport chain.

In a totally oxidized form, it works in the production of energy and in a completely reduced form, it functions as an antioxidant releasing one or two of the electrons that leads to free radicals in its vicinity. These two main functions of CoQ10 in the body define its benefits for the health of humanity.

CoQ10 Health Benefits

CoQ10, as I mentioned, is found in every cell of the body, more so in the body's organs that require more energy for its functions. Organs such as the heart, liver and kidneys. The effect of CoQ10 on diseases has not been determined conclusively. However, there is some evidence that CoQ10 plays certain roles in some diseases that affect man.

Cancer

Researchers showed in the early 1960s that the blood level of CoQ10 was low in some types of cancer. This list includes diseases such as cancer of the colon, prostate, breast, pancreas, kidney, myeloma, lymphoma, etc. In addition to the increased production of energy for cell growth and maintenance, CoQ10 can also help stimulate the immune system to attack cancer cells.

Cardiovascular Health

Heart Failure

The role of CoQ10 in the treatment of heart failure has not been established. However, supplementation with CoQ10 can be used in conjunction with conventional pharmacological treatment for heart failure. The evidence shows that it could improve the symptoms of heart failure.

In general terms, CoQ10 has a positive effect on cardiovascular health. Because of its high concentration in the heart muscle, it helps the heart muscles function optimally, a process that can help regulate blood pressure. Not only that, CoQ10 helps maintain the state of LDL cholesterol in a state of healthy oxidation. All of these help keep blood vessels in optimal health. The result is that conditions such as hypertension, stroke, coronary heart disease, etc. are prevented.

It has been found that CoQ10, which is found predominantly in mitochondria, reduces the frequency and severity of migraine. Migraine headache itself is a condition that has its roots in the mitochondria.

CoQ10 also improves male fertility by improving the quality and characteristics of sperm cells. The motility of the sperm cells is what is most positively affected in this case. Other health benefits of CoQ10 are the prevention of gingivitis (inflammation of the gums) and the prevention and treatment of Parkinson's disease in high doses.

CoQ10 sources

CoQ10 can be made available to the body from 3 sources. The first is by synthesis in the body. Second, you can get it from the food. The common food sources of CoQ10 are beef and chicken heart, fish such as sardines, tuna, mackerel and salmon. Olive, soy and sunflower oils contain CoQ10, as well as peanuts, sesame seeds, walnuts, almonds and hazelnuts. The sources of vegetables and fruits are parsley, broccoli, spinach, cauliflower and avocado.

CoQ10 supplements can be purchased at health food stores.

Conditions associated with CoQ10 deficiency

Two conditions that can lead to CoQ10 deficiency decreases biosynthesis as in the use of statins that block CoQ10 synthesis. The second is greater use by the body. In diseases such as heart failure, muscular dystrophy and cancer, the use of CoQ10 tends to increase and could lead to a deficiency.

The following diseases may be associated with the deficiency: high blood pressure, cardiac arrhythmias, heart failure, angina pectoris, altered blood sugar control, and gastrointestinal tract diseases such as gingivitis and stomach ulcers.


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