A 10-year-old boy with a rare disease related to COVID-19 endures 4 amputations


A 10-year-old boy in Michigan has suffered four hand and leg amputations after a rare episode of a severe inflammatory disease related to the coronavirus.

Dae’Shun Jamison was diagnosed with Multisystemic Inflammatory Syndrome in Children (MIS-C) and had his right leg amputated in early February at Helen DeVos Children’s Hospital, a spokesperson for Mary Free Bed Rehabilitation Hospital, where the boy entered rehab. and recovery, confirmed. to Fox News. The boy was transferred back to Helen DeVos Children’s Hospital on Monday for amputations of both hands and left leg.

Brittney Autman, the boy’s mother, detailed the story on a related GoFundMe page, writing Tuesday, “Dae’Shun is very excited about his amputations and it breaks my heart. Please keep praying. “

Patients battling this rare and serious inflammatory condition could experience the loss of a limb due to a hyper-inflammatory response that affects the body’s blood clotting ability, an expert explained.

According to Dr. Rosemary Olivero, chief of pediatric infectious diseases at Helen DeVos Children’s Hospital, some patients with MIS-C suffer from severe heart dysfunction, which affects the way the body pumps blood to the rest of the body. Heart dysfunction, along with blood clotting or bleeding problems, can be exacerbated to obstruct blood flow throughout the body, he said.

Autman said his son needed to have his hands amputated “due to lack of blood flow and damaged tissues in the hands,” and also wrote last month: “Dae’Shun has [sic] had a blood clot in the artery in your right hand for more than 2 weeks and the blood thinners you are taking are [sic] it does not work…”

Cardiac dysfunction along with blood clotting and bleeding problems can lead to loss of a limb in MIS-C patients, according to one expert.
Cardiac dysfunction along with blood clotting and bleeding problems can lead to loss of a limb in MIS-C patients, according to one expert.
Mary Free Bed Rehabilitation Hospital

“Some patients with MIS-C have really extreme changes in their blood clotting factors. Some of them can clot too much in some parts of your body and then too little in other parts of your body, “Olivero said, adding later,” Inappropriate clotting is one of the very serious consequences of MIS-C. It does not occur in all patients, but it can occur in some and can actually lead to further organ damage due to the mechanics of blood flow. “

While medical professionals have become more adept at standardized care for MIS-C, the syndrome remains incredibly challenging due to the complex nature of the disease, Olivero said.

When the boy was informed of the amputations in January, Autman wrote: “He got it all. He understood that when he [would] wake up your leg won’t look the same. Dae’Shun burst into tears completely, which affected [sic] me in many ways. “

The boy had been battling a severe course of the disease over the winter, and his mother detailed his treatment that included kidney dialysis, lung support and a feeding tube.

Olivero said the MIS-C-derived amputations are “a unique and unfortunate consequence.”

MIS-C usually arises several weeks after a previous COVID-19 infection and can cause organ damage due to a hyper-inflammatory response.

While medical professionals have become more adept at standardized care for MIS-C, the syndrome remains incredibly challenging due to the complex nature of the disease.
While medical professionals have become more adept at standardized care for MIS-C, the syndrome remains incredibly challenging due to the complex nature of the disease.
Mary Free Bed Rehabilitation Hospital

“Your body is excreting a ton of inflammatory chemicals that actually spread the immune system, which can be very damaging to the body’s organs,” Olivero explained, detailing MIS-C.

The treatments aim to alleviate an intense inflammatory response that involves a reaction to the infection. More specifically, the treatments involve IVIG (intravenous immunoglobulin treatment) or groups of antibodies with particularly strong anti-inflammatory characteristics, as well as steroids to calm the immune system. Children with persistent inflammatory problems or those requiring intensive care may be given more specific anti-inflammatories or immunomodulators.

If a child is infected with COVID-19, they generally tend to do better and only develop mild or asymptomatic illness. This could make it difficult for parents to detect a case of MIS-C early. However, significant community transmission of COVID-19 will likely increase the prevalence of MIS-C and parents should monitor children for signs such as fever, vomiting, abdominal pain, diarrhea, inflammation of the skin, eyes, hands or feet. , acne. or reddened lips or eyes, Olivero said. Some children have swollen hands or feet, while others have enlarged lymph nodes.

The expert recommended that any parent with concern about MIS-C contact their physician immediately for an evaluation.

According to data from the Centers for Disease Control and Prevention (CDC), as of February 1, more than 2,000 cases of MIS-C have been reported across the country, disproportionately affecting minority populations.

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