Mostert led the team with 95 yards and a score to go with 56 yards on the field.
2. For the first half, San Francisco’s defensive line managed to keep the pressure on Murray. Nick Bosa, Jevon Kinlaw and Solomon Thomas all saw quarterback pressures. Kinlaw registered a run stop against the Cardinals running back Kenyan Drake. The second-year quarterback gained his footing in the second half, as the 49ers struggled to pace the QB. Murray led the Cardinals with 91 yards rushing, and finished the game with 230 yards on the air, one score and one interception.
3. Newcomer Carey Hyder Jr. scored 49th in the first match of the season. Hyder Jr. was signed by the team at the start of free agency by way of the Dallas Cowboys. DJ Jones was also credited with a sack.
4. DeAndre is Hopkins, and is likely to remain a problem for the 49ers. Arizona’s new wideout averaged 151 yards on 14 catches, including an unopened near-touchdown. Richard Sherman overshadowed DeAndre Hopkins during various points of the day – a new wrinkle for the 49ers cornerback who has played mainly on the left side of the field for most of his 10-year career.
“I was playing for the open side,” Sherman said. “Wherever there was more field, the same side I was playing. It was an adjustment to (49ers defensive coordinator Robert) Saleh.”
5. The first takeaway of the season was a tricky ball by Dre Greenlaw on a pass to Scramage on a pass to wide open Cardinals tight end Maxx Williams. The pass landed from the hands of Jaquiski Tartt, who returned the ball 16 yards to Arizona’s 26-yard line. Tartt’s blocking marked his first since 2018, a pick against former Cardinals quarterback Josh Rosen in Week 8 of the regular season.
6. George Cabet left the game before the half, with a leg injury. The tight end, however, did not register a single reception in the second half. Kittle finished the game with four receptions for 44 yards.
7. The 49ers scored their only Red Zone touchdown in the fourth yard with a wide-open pass to Jerich McKinnon from 5-yards out. San Francisco opened the drive with a 41-yard bomb from Garoppolo to Kyle Juszski. A pass interfer call three plays later moved the 49ers to the Cardinals 10 to help set up a touchdown. That mark marked McKinnon’s first touchdown since December 3, 2017 with the Minnesota Vikings.
In his early 49s, Mackinnon caught three receptions for 20 yards to go with his score, and tackled another 24 on the ground.
8. Not his biggest outing, but Garapolo finished the day with a 103.0 passer rating for 259 yards and two touchdowns from 19–33.
- Richie James left the game in the second half with a hamstring injury. No updates on severity yet.
- Jordan Reid made his 49th debut, hitting both of his targets for 12 yards.
- Trent Williams could go viral with his run block against Cardinals linebacker Jordan Hicks. The left tackle dropped the line of scrimmage and caught the defender by going to another level. Former NFL guard Geoff Schwartz Quickly took notice of the play, Which saw (and counting) more than 1.2 million times.