Scientists have found a new gene that can be critical in the regulation of insulin, the key hormone in diabetes, from a family with high and low blood sugar levels. Diabetes is a group of diseases that produce too much sugar in the blood (high blood glucose level). According to the WHO, by the year 2030, diabetes would become one of the main killers worldwide.
According to the study published in the journal PNAS, in addition to type 1 or type 2 diabetes, almost 1-2 percent of the cases of the blood sugar condition are due to a deterioration in a gene called MAFA, which can affect the production of insulin and also cause insulinomas, tumors that produce insulin in the pancreas.
These tumors are usually triggered by low blood sugar levels, in contrast to diabetes, leading to high blood sugar levels.
"At first we were surprised by the association of two apparently contradictory conditions within the same families: diabetes associated with high blood sugar levels and insulinomas associated with low blood sugar levels," said lead author Marta Korbonits. , Professor at the Queen Mary University of London (QMUL).
"Our research shows that, surprisingly, the same gene defect can affect the insulin-producing beta cells of the pancreas to lead to these two opposing medical conditions," Korbonits added.
Another important revelation made by the study was the link between diabetes and gender. The findings revealed that men were more likely to develop diabetes, while insulinomas were more commonly found in women, but the reasons behind this difference are still unknown.
For the study, the team studied a family, with a single case in which several individuals had diabetes, while other members developed insulinomas in the pancreas.
The findings could be an innovative intervention in the field of diabetes control. This is the first time that a defect in the MAFA gene has been linked to a disease. It was found that the resulting mutant protein was abnormally stable, that it had a longer life in the cell and, therefore, was significantly more abundant in beta cells than its normal version.
There are many things you can do on the domestic front to help control diabetes better. Your diet plays a very important role. These nutritious foods not only help control diabetes but can also prevent the risk of diabetes.
1. Green leafy vegetables: Kale, mustard greens, turnip greens and methi are low in calories and carbohydrates and, therefore, do not cause sudden peaks in the blood sugar levels. They are also replete with fiber and vitamin C, which acts as a powerful antioxidant.
2. Bitter gourd: Bitter gourd contains active substances that provide antidiabetic properties, such as charantine, known for its hypoglycaemic effect and an insulin-like compound known as p-polypeptide. The best way to consume it is to drink fresh bitter gourd juice early in the morning on an empty stomach.
3. Whole Grains : Whole grains, such as barley and oats, are full of fiber and are digested slowly to keep the blood sugar from spiking suddenly. The consumption of whole grains helps prevent weight gain, which is a major risk factor for diabetes.
4. Flaxseed and squash seeds: Flaxseed contains large amounts of an insoluble fiber called lignan. Flax seeds help reduce the chances of heart complications and also the risk of stroke related to diabetes. Keep a handful of pumpkin seeds with you to combat the cravings for fatty and sugary foods.